Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage

Praveen Rishi, Swapandeep Kaur Mavi, Sushma Bharrhan, Geeta Shukla, Rupinder Tewari

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

In view of the increasing interest in the bioecological and nutritional control of diseases, use of probiotics alone or in combination with prebiotics (synbiotics) appears as a therapeutic option for various diseases. In this study, an attempt was made to explore the protective potential of Lactobacillus acidophilus as a probiotic, inulin as a prebiotic and both L. acidophilus and inulin as synbiotic against Salmonella-induced liver damage in a murine model. The probiotic, prebiotic and synbiotic supplementation resulted in decreased bacterial translocation in the liver of mice challenged with Salmonella typhimurium and decreased levels of serum aminotransferases, suggesting their protective role against Salmonella infection. Mice supplemented with these preparations before Salmonella challenge also revealed decreased levels of lipid peroxidation, increased levels of superoxide dismutase and glutathione, along with reduced levels of nitric oxide. Thus, bacteriological and biochemical alterations correlated well with the histological evidence. Protection afforded by supplementation with the probiotic alone was found to be more effective. None of the observations was suggestive of the synergistic effect in the synbiotic-supplemented animals. Thus, it is indicated that the probiotic and the prebiotic used in the present study may act by different mechanisms involved in affording protection against Salmonella-induced liver damage.

Original languageEnglish (US)
Pages (from-to)222-230
Number of pages9
JournalFEMS Microbiology Ecology
Volume69
Issue number2
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

Fingerprint

Prebiotics
Synbiotics
probiotics
Probiotics
Salmonella
damage
Liver
Lactobacillus acidophilus
Inulin
Bacterial Translocation
Salmonella Infections
nitric oxide
Salmonella typhimurium
Transaminases
translocation
Lipid Peroxidation
Superoxide Dismutase
Glutathione
serum
Nitric Oxide

Keywords

  • Lactobacillus acidophilus
  • Liver damage
  • Probiotic
  • Salmonella

ASJC Scopus subject areas

  • Microbiology
  • Ecology
  • Applied Microbiology and Biotechnology

Cite this

Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage. / Rishi, Praveen; Mavi, Swapandeep Kaur; Bharrhan, Sushma; Shukla, Geeta; Tewari, Rupinder.

In: FEMS Microbiology Ecology, Vol. 69, No. 2, 01.08.2009, p. 222-230.

Research output: Contribution to journalArticle

Rishi, Praveen ; Mavi, Swapandeep Kaur ; Bharrhan, Sushma ; Shukla, Geeta ; Tewari, Rupinder. / Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage. In: FEMS Microbiology Ecology. 2009 ; Vol. 69, No. 2. pp. 222-230.
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