Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats

Sangeetha Thangaswamy, S. Darlin Quine

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The antihyperlipidemic, antilipoperoxidative and antioxidant effects of S-allyl cysteine sulphoxide (SACS) in myocardial infarcted rats were reported previously. The present study was undertaken to evaluate the preventive role of SACS on some biochemical parameters, glycoproteins and hematology in experimentally induced myocardial infarction in rats. Myocardial infarction was induced in rats by subcutaneous injection of isoproterenol (ISO) (150 mg kg -1) at an interval of 24 h for 2 days. ISO-treated rats showed a significant increase in the levels of serum iron, uric acid and blood glucose, Na+ and Ca2+ in the heart and a significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K+ and heart glycogen. The levels/concentrations of glycoproteins in serum and the heart were increased in myocardial infarcted rats. Myocardial infarcted rats also showed a significant increase in red blood cells, hemoglobin, packed cell volume, white blood cells, neutrophils, platelet count and fibrinogen level and a significant decrease in erythrocyte sedimentation rate, eosinophils, lymphocytes, bleeding, clotting and prothrombin time. Oral pretreatment with SACS (40 and 80 mg kg-1) daily for a period of 35 days showed a positive effect on all the biochemical parameters studied in ISO-induced rats. Thus, the study showed the protective effect of SACS on ISO-induced cardiotoxicity in male Wistar rats.

Original languageEnglish (US)
Pages (from-to)710-716
Number of pages7
JournalJournal of Applied Toxicology
Volume28
Issue number5
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Hematology
Isoproterenol
Wistar Rats
Rats
Glycoproteins
Myocardial Infarction
Iron
Blood
Hypolipidemic Agents
Cells
Bleeding Time
Blood Sedimentation
Prothrombin Time
Globulins
Subcutaneous Injections
Lymphocytes
alliin
S-allylcysteine
Uric Acid
Serum

Keywords

  • Alliin
  • Glycoproteins
  • Hematology
  • Isoproterenol
  • Myocardial infarction

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats. / Thangaswamy, Sangeetha; Quine, S. Darlin.

In: Journal of Applied Toxicology, Vol. 28, No. 5, 07.2008, p. 710-716.

Research output: Contribution to journalArticle

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