Protective antibodies and endemic dimorphic fungi

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The host response to infection is the outcome of a complex interaction between a microbe and a host's innate and adaptive immune system. In this context, the role of antibody in the endemic mycoses is relatively poorly understood. Recently, a monoclonal antibody to a cell surface protein has been shown to be protective in a murine histoplasmosis model. The findings with Histoplasma capsulatum may provide a paradigm for antibody protection against endemic fungi. This paper reviews the recent data on protective antibody in histoplasmosis and previous data supporting a role for antibody in protective responses in other dimorphic fungi.

Original languageEnglish (US)
Pages (from-to)435-442
Number of pages8
JournalCurrent Molecular Medicine
Volume5
Issue number4
DOIs
StatePublished - Jun 2005

Keywords

  • Antibody
  • Histoplasma capsulatum
  • Pathogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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