Abstract
The host response to infection is the outcome of a complex interaction between a microbe and a host's innate and adaptive immune system. In this context, the role of antibody in the endemic mycoses is relatively poorly understood. Recently, a monoclonal antibody to a cell surface protein has been shown to be protective in a murine histoplasmosis model. The findings with Histoplasma capsulatum may provide a paradigm for antibody protection against endemic fungi. This paper reviews the recent data on protective antibody in histoplasmosis and previous data supporting a role for antibody in protective responses in other dimorphic fungi.
Original language | English (US) |
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Pages (from-to) | 435-442 |
Number of pages | 8 |
Journal | Current Molecular Medicine |
Volume | 5 |
Issue number | 4 |
DOIs | |
State | Published - Jun 2005 |
Keywords
- Antibody
- Histoplasma capsulatum
- Pathogenesis
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology