Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell

Jean Mukherjee, Gabriel Nussbaum, Matthew D. Scharff, Arturo Casadevall

Research output: Contribution to journalArticle

140 Scopus citations

Abstract

Two immunoglobulin M monodonal antibodies (mAbs) derived from the same B cell recognize different epitopes on the capsular polysaccharide of the pathogenic yeast, Cryptococcus , eoformans. Their respective epitopes are located in spatially distinct regions of the capsule. Passive administration of one mAb prolonged survival whereas the other mAb did not. The results indicate that specificity is an important determinant of antibody efficacy against C. , eoformans and that somatic mutations occurring during the antibody response can affect the protective efficacy of antibodies to C. neoformans.

Original languageEnglish (US)
Pages (from-to)405-409
Number of pages5
JournalJournal of Experimental Medicine
Volume181
Issue number1
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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