TY - JOUR
T1 - Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs
AU - Sampson, Samantha L.
AU - Dascher, Christopher C.
AU - Sambandamurthy, Vasan K.
AU - Russell, Robert G.
AU - Jacobs, William R.
AU - Bloom, Barry R.
AU - Hondalus, Mary K.
PY - 2004/5
Y1 - 2004/5
N2 - We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The ΔleuD ΔpanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease pathology.
AB - We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The ΔleuD ΔpanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease pathology.
UR - http://www.scopus.com/inward/record.url?scp=2142708662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2142708662&partnerID=8YFLogxK
U2 - 10.1128/IAI.72.5.3031-3037.2004
DO - 10.1128/IAI.72.5.3031-3037.2004
M3 - Article
C2 - 15102816
AN - SCOPUS:2142708662
SN - 0019-9567
VL - 72
SP - 3031
EP - 3037
JO - Infection and immunity
JF - Infection and immunity
IS - 5
ER -
