Protection against fatal murine Chagas' disease with a Leishmania braziliensis panamensis stock

H. B. Tanowitz, B. Amole, R. Herman, M. Wittner

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Past attempts to immunize mice against a fatal Trypanosoma cruzi infection utilizing related hemoflagellates have been unsuccessful. In the present study, C57BL/6 mice received a footpad inoculation of 107 promastigotes of Leishmania braziliensis panamensis. Six and 9 weeks subsequent to this inoculation mice were infected intraperitoneally with the Tulahuen strain of T. cruzi. All immunized mice survived infection over the 6-month period of observation whereas control mice regularly died. There was an early transient T. cruzi parasitemia in the immunized mice. Culture of blood and organs as well as histopathological examination of various organs 6 months post-challenge failed to yield any evidence of T. cruzi. Heat-killed and freeze-thawed extracts of promastigotes did not confer any protection. These observations raise the possibility that certain leishmanial species might confer natural protection against a T. cruzi infection and that this information could be useful in the development of a vaccine.

Original languageEnglish (US)
Pages (from-to)937-941
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume35
Issue number5
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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