Proteasomes associated with the blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein dnm1

Krisztina Tar, Thomas Dange, Ciyu Yang, Yanhua Yao, Anne Laure Bulteau, Elena Fernandez Salcedo, Stephen Braigen, Frederic Bouillaud, Daniel Finley, Marion Schmidt

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: Blm10 binds to the proteasome core particle and stimulates its proteolytic activity. Results: Loss of BLM10 results in impaired respiration, elevated oxidative stress sensitivity, increased mitochondrial fission, and stabilization of the fission protein Dnm1. Conclusion: Blm10 proteasome-mediated Dnm1 degradation is a regulatory mechanism to maintain correct mitochondrial function. Significance: Blm10 is involved in mitochondrial quality control under oxidative stress.

Original languageEnglish (US)
Pages (from-to)12145-12156
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - Apr 25 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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