Protease resistant protein cellular isoform (PrPc) as a biomarker: Clues into the pathogenesis of HAND

Bezawit Megra, Eliseo Eugenin, Toni Roberts, Susan Morgello, Joan W. Berman

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

HIV infection and HIV neurocognitive impairment are major global health problems. The prevalence of HIV associated neurocognitive disorders (HAND) is increasing as people with HIV are living longer due to the success of antiretroviral therapies. Our laboratory identified the soluble form of (sPrPc), the cellular non-pathogenic isoform of the prion protein, as a biomarker of HAND. In this review we discuss the published data addressing PrPc biology in normal conditions and pathologies, as well as the mechanisms of sPrPc shedding and secretion. Lastly, we discuss our studies that demonstrated that sPrPc is a biomarker of neurocognitive impairment in the HIV infected population.

Original languageEnglish (US)
Pages (from-to)1159-1166
Number of pages8
JournalJournal of Neuroimmune Pharmacology
Volume8
Issue number5
DOIs
StatePublished - Dec 1 2013

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Keywords

  • Astrocytes
  • Dementia
  • HIV
  • NeuroAIDS
  • Prion

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

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