Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon

Frank A.J. Konings; Ping Zhong; Moise Agwara; Lucy Agyingi; Leopold Zekeng; Jacqueline M. Achkar; Leonard Ewane; Saa; Emmanuel Afane Ze; Thompson Kinge; Phillipe N. Nyambi

doi:10.1089/088922204322749558

Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon

Frank A.J. Konings, Ping Zhong, Moise Agwara, Lucy Agyingi, Leopold Zekeng, Jacqueline M. Achkar, Leonard Ewane, Saa, Emmanuel Afane Ze, Thompson Kinge, Phillipe N. Nyambi

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.

Original language	English (US)
Pages (from-to)	105-109
Number of pages	5
Journal	AIDS Research and Human Retroviruses
Volume	20
Issue number	1
DOIs	https://doi.org/10.1089/088922204322749558
State	Published - Jan 2004
Externally published	Yes

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon",

abstract = "To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.",

author = "Konings, {Frank A.J.} and Ping Zhong and Moise Agwara and Lucy Agyingi and Leopold Zekeng and Achkar, {Jacqueline M.} and Leonard Ewane and Saa and Ze, {Emmanuel Afane} and Thompson Kinge and Nyambi, {Phillipe N.}",

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AU - Konings, Frank A.J.

AU - Zhong, Ping

AU - Agwara, Moise

AU - Agyingi, Lucy

AU - Zekeng, Leopold

AU - Achkar, Jacqueline M.

AU - Ewane, Leonard

AU - Saa,

AU - Ze, Emmanuel Afane

AU - Kinge, Thompson

AU - Nyambi, Phillipe N.

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N2 - To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.

AB - To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.

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Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon

Abstract

ASJC Scopus subject areas

UN SDGs

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