Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon

Frank A J Konings, Ping Zhong, Moise Agwara, Lucy Agyingi, Leopold Zekeng, Jacqueline M. Achkar, Leonard Ewane, Saa, Emmanuel Afane Ze, Thompson Kinge, Phillipe N. Nyambi

Research output: Contribution to journalArticle

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Abstract

To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume20
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

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Cameroon
HIV-1
Peptide Hydrolases
Mutation
Protease Inhibitors
Pharmaceutical Preparations
Viruses
Genes

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon. / Konings, Frank A J; Zhong, Ping; Agwara, Moise; Agyingi, Lucy; Zekeng, Leopold; Achkar, Jacqueline M.; Ewane, Leonard; Saa; Ze, Emmanuel Afane; Kinge, Thompson; Nyambi, Phillipe N.

In: AIDS Research and Human Retroviruses, Vol. 20, No. 1, 01.2004, p. 105-109.

Research output: Contribution to journalArticle

Konings, FAJ, Zhong, P, Agwara, M, Agyingi, L, Zekeng, L, Achkar, JM, Ewane, L, Saa, Ze, EA, Kinge, T & Nyambi, PN 2004, 'Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon', AIDS Research and Human Retroviruses, vol. 20, no. 1, pp. 105-109. https://doi.org/10.1089/088922204322749558
Konings, Frank A J ; Zhong, Ping ; Agwara, Moise ; Agyingi, Lucy ; Zekeng, Leopold ; Achkar, Jacqueline M. ; Ewane, Leonard ; Saa ; Ze, Emmanuel Afane ; Kinge, Thompson ; Nyambi, Phillipe N. / Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon. In: AIDS Research and Human Retroviruses. 2004 ; Vol. 20, No. 1. pp. 105-109.
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