Prospects of vaccines for invasive aspergillosis

Marta Feldmesser

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Invasive aspergillosis is a disease of immunocompromised hosts and the pathogenesis of this disorder is heavily dependent upon the defect within a given host. Consequently, vaccine development is limited by our understanding of effective host responses and by limitations in our knowledge of fungal molecules that elicit protective immunity. Nonetheless, the past few years have witnessed advances in our understanding both of the immune response to this organism and in the relationship between antigenicity and the ability to confer protection. Manipulations that promote the development of TH1-associated responses correlate with increased resistance to disease, at least partly because of consequent enhancement of innate cellular effector function. Two areas of investigation most actively being pursued include the search for adjuvants that will allow products of Aspergillus fumigatus to become effective vaccine candidates, regardless of the form of immunity they ordinarily induce, and the identification of the specific antigens that will most effectively elicit beneficial responses. Strategies using antigen-exposed dendritic cells as adjuvants appear to be particularly promising. Though we currently are far away from a candidate that is applicable for human trials, recent progress is encouraging.

Original languageEnglish (US)
Pages (from-to)571-587
Number of pages17
JournalMedical Mycology
Volume43
Issue number7
DOIs
StatePublished - Nov 2005

Fingerprint

Aspergillosis
aspergillosis
adjuvants
Immunity
Vaccines
immunity
vaccines
antigens
immunocompromised population
Antigens
Disease Resistance
Aspergillus fumigatus
vaccine development
Immunocompromised Host
dendritic cells
Dendritic Cells
pathogenesis
immune response
organisms

Keywords

  • Aspergillus fumigatus
  • Invasive aspergillosis
  • Vaccine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)
  • Microbiology

Cite this

Prospects of vaccines for invasive aspergillosis. / Feldmesser, Marta.

In: Medical Mycology, Vol. 43, No. 7, 11.2005, p. 571-587.

Research output: Contribution to journalArticle

Feldmesser, Marta. / Prospects of vaccines for invasive aspergillosis. In: Medical Mycology. 2005 ; Vol. 43, No. 7. pp. 571-587.
@article{a84cec1962634b03b2ef1407267b00bd,
title = "Prospects of vaccines for invasive aspergillosis",
abstract = "Invasive aspergillosis is a disease of immunocompromised hosts and the pathogenesis of this disorder is heavily dependent upon the defect within a given host. Consequently, vaccine development is limited by our understanding of effective host responses and by limitations in our knowledge of fungal molecules that elicit protective immunity. Nonetheless, the past few years have witnessed advances in our understanding both of the immune response to this organism and in the relationship between antigenicity and the ability to confer protection. Manipulations that promote the development of TH1-associated responses correlate with increased resistance to disease, at least partly because of consequent enhancement of innate cellular effector function. Two areas of investigation most actively being pursued include the search for adjuvants that will allow products of Aspergillus fumigatus to become effective vaccine candidates, regardless of the form of immunity they ordinarily induce, and the identification of the specific antigens that will most effectively elicit beneficial responses. Strategies using antigen-exposed dendritic cells as adjuvants appear to be particularly promising. Though we currently are far away from a candidate that is applicable for human trials, recent progress is encouraging.",
keywords = "Aspergillus fumigatus, Invasive aspergillosis, Vaccine",
author = "Marta Feldmesser",
year = "2005",
month = "11",
doi = "10.1080/13693780500402138",
language = "English (US)",
volume = "43",
pages = "571--587",
journal = "Medical Mycology",
issn = "1369-3786",
publisher = "Informa Healthcare",
number = "7",

}

TY - JOUR

T1 - Prospects of vaccines for invasive aspergillosis

AU - Feldmesser, Marta

PY - 2005/11

Y1 - 2005/11

N2 - Invasive aspergillosis is a disease of immunocompromised hosts and the pathogenesis of this disorder is heavily dependent upon the defect within a given host. Consequently, vaccine development is limited by our understanding of effective host responses and by limitations in our knowledge of fungal molecules that elicit protective immunity. Nonetheless, the past few years have witnessed advances in our understanding both of the immune response to this organism and in the relationship between antigenicity and the ability to confer protection. Manipulations that promote the development of TH1-associated responses correlate with increased resistance to disease, at least partly because of consequent enhancement of innate cellular effector function. Two areas of investigation most actively being pursued include the search for adjuvants that will allow products of Aspergillus fumigatus to become effective vaccine candidates, regardless of the form of immunity they ordinarily induce, and the identification of the specific antigens that will most effectively elicit beneficial responses. Strategies using antigen-exposed dendritic cells as adjuvants appear to be particularly promising. Though we currently are far away from a candidate that is applicable for human trials, recent progress is encouraging.

AB - Invasive aspergillosis is a disease of immunocompromised hosts and the pathogenesis of this disorder is heavily dependent upon the defect within a given host. Consequently, vaccine development is limited by our understanding of effective host responses and by limitations in our knowledge of fungal molecules that elicit protective immunity. Nonetheless, the past few years have witnessed advances in our understanding both of the immune response to this organism and in the relationship between antigenicity and the ability to confer protection. Manipulations that promote the development of TH1-associated responses correlate with increased resistance to disease, at least partly because of consequent enhancement of innate cellular effector function. Two areas of investigation most actively being pursued include the search for adjuvants that will allow products of Aspergillus fumigatus to become effective vaccine candidates, regardless of the form of immunity they ordinarily induce, and the identification of the specific antigens that will most effectively elicit beneficial responses. Strategies using antigen-exposed dendritic cells as adjuvants appear to be particularly promising. Though we currently are far away from a candidate that is applicable for human trials, recent progress is encouraging.

KW - Aspergillus fumigatus

KW - Invasive aspergillosis

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=30644475738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30644475738&partnerID=8YFLogxK

U2 - 10.1080/13693780500402138

DO - 10.1080/13693780500402138

M3 - Article

C2 - 16396243

AN - SCOPUS:30644475738

VL - 43

SP - 571

EP - 587

JO - Medical Mycology

JF - Medical Mycology

SN - 1369-3786

IS - 7

ER -