Prospects for imaging-related biomarkers of human epileptogenesis: A critical review

William A. Gomes, Shlomo Shinnar

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To facilitate the study of epileptogenesis in humans, noninvasive biomarkers of epileptogenesis are required. No validated biomarker is currently available, but brain imaging techniques provide many attractive candidates. In this article we examine the imaging features of temporal lobe epilepsy, focusing on those that may precede the onset of epilepsy and correlate with epileptogenesis. Hippocampal volumetry and T 2 relaxometry are proposed as candidate biomarkers of epileptogenesis in temporal lobe epilepsy following febrile status epilepticus. Preliminary data suggest that these have promise, and the ongoing Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) study will provide more conclusive evidence as to their validity. At this time there are no other clear candidates for imaging-related biomarkers of epileptogenesis in human studies.

Original languageEnglish (US)
Pages (from-to)599-606
Number of pages8
JournalBiomarkers in Medicine
Volume5
Issue number5
DOIs
StatePublished - Oct 2011

Fingerprint

Biomarkers
Imaging techniques
Temporal Lobe Epilepsy
Febrile Seizures
Status Epilepticus
Neuroimaging
Epilepsy
Brain
Fever

Keywords

  • biomarker
  • epilepsy
  • epileptogenesis
  • febrile status epilepticus
  • MRI

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

Cite this

Prospects for imaging-related biomarkers of human epileptogenesis : A critical review. / Gomes, William A.; Shinnar, Shlomo.

In: Biomarkers in Medicine, Vol. 5, No. 5, 10.2011, p. 599-606.

Research output: Contribution to journalArticle

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