Prospective longitudinal analysis of quantitative Epstein-Barr virus polymerase chain reaction in pediatric liver transplant recipients

Debora Kogan-Liberman, M. Burroughs, S. Emre, T. Fishbein, A. Moscona, C. Ramson, B. L. Shneider

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background. Posttransplant lymphoproliferative disease (PTLD) remains a significant cause of morbidity and mortality in pediatric liver transplant recipients. Epstein-Barr Virus (EBV) mismatch associated with more prevalent use of split-liver, reduced size, and living-related transplants has increased the risk of primary EBV infection and subsequent PTLD. Early identification of EBV viremia may reduce the risk of PTLD, because it allows for early adjustment of immunosuppression and antiviral therapy. Methods. EBV vital load was measured monthly by quantitative competitive polymerase chain reactions in three pediatric liver transplant recipients. Results. Onset of EBV viremia was documented in one recipient. Established EBV viremia was followed in the other two recipients (one with chronic rejection and one with PTLD) who were initially tested once monitoring was initiated in our program. Conclusions. EBV quantitative competitive polymerase chain reactions may represent a promising way to follow EBV vital load and potentially prevent the development of PTLD.

Original languageEnglish (US)
Pages (from-to)1068-1070
Number of pages3
JournalTransplantation
Volume67
Issue number7
DOIs
StatePublished - Apr 15 1999

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Human Herpesvirus 4
Pediatrics
Polymerase Chain Reaction
Liver
Viremia
Epstein-Barr Virus Infections
Transplant Recipients
Immunosuppression
Antiviral Agents
Morbidity
Transplants
Mortality

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Prospective longitudinal analysis of quantitative Epstein-Barr virus polymerase chain reaction in pediatric liver transplant recipients. / Kogan-Liberman, Debora; Burroughs, M.; Emre, S.; Fishbein, T.; Moscona, A.; Ramson, C.; Shneider, B. L.

In: Transplantation, Vol. 67, No. 7, 15.04.1999, p. 1068-1070.

Research output: Contribution to journalArticle

Kogan-Liberman, Debora ; Burroughs, M. ; Emre, S. ; Fishbein, T. ; Moscona, A. ; Ramson, C. ; Shneider, B. L. / Prospective longitudinal analysis of quantitative Epstein-Barr virus polymerase chain reaction in pediatric liver transplant recipients. In: Transplantation. 1999 ; Vol. 67, No. 7. pp. 1068-1070.
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AU - Burroughs, M.

AU - Emre, S.

AU - Fishbein, T.

AU - Moscona, A.

AU - Ramson, C.

AU - Shneider, B. L.

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N2 - Background. Posttransplant lymphoproliferative disease (PTLD) remains a significant cause of morbidity and mortality in pediatric liver transplant recipients. Epstein-Barr Virus (EBV) mismatch associated with more prevalent use of split-liver, reduced size, and living-related transplants has increased the risk of primary EBV infection and subsequent PTLD. Early identification of EBV viremia may reduce the risk of PTLD, because it allows for early adjustment of immunosuppression and antiviral therapy. Methods. EBV vital load was measured monthly by quantitative competitive polymerase chain reactions in three pediatric liver transplant recipients. Results. Onset of EBV viremia was documented in one recipient. Established EBV viremia was followed in the other two recipients (one with chronic rejection and one with PTLD) who were initially tested once monitoring was initiated in our program. Conclusions. EBV quantitative competitive polymerase chain reactions may represent a promising way to follow EBV vital load and potentially prevent the development of PTLD.

AB - Background. Posttransplant lymphoproliferative disease (PTLD) remains a significant cause of morbidity and mortality in pediatric liver transplant recipients. Epstein-Barr Virus (EBV) mismatch associated with more prevalent use of split-liver, reduced size, and living-related transplants has increased the risk of primary EBV infection and subsequent PTLD. Early identification of EBV viremia may reduce the risk of PTLD, because it allows for early adjustment of immunosuppression and antiviral therapy. Methods. EBV vital load was measured monthly by quantitative competitive polymerase chain reactions in three pediatric liver transplant recipients. Results. Onset of EBV viremia was documented in one recipient. Established EBV viremia was followed in the other two recipients (one with chronic rejection and one with PTLD) who were initially tested once monitoring was initiated in our program. Conclusions. EBV quantitative competitive polymerase chain reactions may represent a promising way to follow EBV vital load and potentially prevent the development of PTLD.

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