Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients

Andrew Campbell, Caterina P. Minniti, Mehdi Nouraie, Manuel Arteta, Sohail Rana, Onyinye Onyekwere, Craig Sable, Gregory Ensing, Niti Dham, Lori Luchtman-Jones, Gregory J. Kato, Mark T. Gladwin, Oswaldo L. Castro, Victor R. Gordeuk

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Low steady state haemoglobin oxygen saturation in patients with sickle cell anaemia has been associated with the degree of anaemia and haemolysis. How much pulmonary dysfunction contributes to low saturation is not clear. In a prospective study of children and adolescents with sickle cell disease aged 3-20 years at steady state and matched controls, 52% of 391 patients versus 24% of 63 controls had steady state oxygen saturation <99% (P < 0·0001), 9% of patients versus no controls had saturation <95% (P = 0·008) and 8% of patients versus no controls had exercise-induced reduction in saturation ≥3%. Decreasing haemoglobin concentration (P ≤ 0·001) and increasing haemolysis (P ≤ 0·003) but not pulmonary function tests were independent predictors of both lower steady-state saturation and exercise-induced reduction in saturation. Neither history of stroke nor history of acute chest syndrome was significantly associated with lower steady-state oxygen saturation or exercise-induced reduction in saturation. Tricuspid regurgitation velocity was higher in patients with lower steady state haemoglobin oxygen saturation (P = 0·003) and with greater decline in oxygen saturation during the six-minute walk (P = 0·022). In conclusion, lower haemoglobin oxygen saturation is independently associated with increasing degrees of anaemia and haemolysis but not pulmonary function abnormalities among children and adolescents with sickle cell disease.

Original languageEnglish (US)
Pages (from-to)352-359
Number of pages8
JournalBritish Journal of Haematology
Volume147
Issue number3
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Hemoglobins
Exercise
Pediatrics
Oxygen
Hemolysis
Anemia
Acute Chest Syndrome
Tricuspid Valve Insufficiency
Lung
Respiratory Function Tests
Stroke
Prospective Studies

Keywords

  • Oxygen saturation
  • Paediatric
  • Pulmonary hypertension
  • Sickle cell disease
  • Six-minute walk

ASJC Scopus subject areas

  • Hematology

Cite this

Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients. / Campbell, Andrew; Minniti, Caterina P.; Nouraie, Mehdi; Arteta, Manuel; Rana, Sohail; Onyekwere, Onyinye; Sable, Craig; Ensing, Gregory; Dham, Niti; Luchtman-Jones, Lori; Kato, Gregory J.; Gladwin, Mark T.; Castro, Oswaldo L.; Gordeuk, Victor R.

In: British Journal of Haematology, Vol. 147, No. 3, 11.2009, p. 352-359.

Research output: Contribution to journalArticle

Campbell, A, Minniti, CP, Nouraie, M, Arteta, M, Rana, S, Onyekwere, O, Sable, C, Ensing, G, Dham, N, Luchtman-Jones, L, Kato, GJ, Gladwin, MT, Castro, OL & Gordeuk, VR 2009, 'Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients', British Journal of Haematology, vol. 147, no. 3, pp. 352-359. https://doi.org/10.1111/j.1365-2141.2009.07854.x
Campbell, Andrew ; Minniti, Caterina P. ; Nouraie, Mehdi ; Arteta, Manuel ; Rana, Sohail ; Onyekwere, Onyinye ; Sable, Craig ; Ensing, Gregory ; Dham, Niti ; Luchtman-Jones, Lori ; Kato, Gregory J. ; Gladwin, Mark T. ; Castro, Oswaldo L. ; Gordeuk, Victor R. / Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients. In: British Journal of Haematology. 2009 ; Vol. 147, No. 3. pp. 352-359.
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