Prospective assessment of the occurrence of anemia in patients with heart failure

Results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry

Kirkwood F. Adams, John H. Patterson, Ron M. Oren, Mandeep R. Mehra, Christopher M. O'Connor, Ileana L. Pina, Alan B. Miller, Jun R. Chiong, Stephanie H. Dunlap, William G. Cotts, Gary M. Felker, Douglas D. Schocken, Todd A. Schwartz, Jalal K. Ghali

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Although a potentially important pathophysiologic factor in heart failure, the prevalence and predictors of anemia have not been well studied in unselected patients with heart failure. Methods: The Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry prospectively studied the prevalence of anemia and the relationship of hemoglobin to health-related quality of life and outcomes among patients with heart failure. A random selection algorithm was used to reduce bias during enrollment of patients seen in specialty clinics or clinics of community cardiologists with experience in heart failure. In this initial report, data on prevalence and correlates of anemia were analyzed in 1,076 of the 1,082 registry patients who had clinical characteristics and hemoglobin determined by finger-stick at baseline. Results: Overall (n = 1,082), the registry patients were 41% female and 73% white with a mean age (±SD) of 64 ± 14 years (68 ± 13 years in community and 57 ± 14 years in specialty sites, P < .001). Among the 1,076 patients in the prevalence analysis, mean hemoglobin was 13.3 ± 2.1 g/dL (median 13.2 g/dL); and anemia (defined by World Health Organization criteria) was present in 34%. Age identified patients at risk for anemia, with 40% of patients >70 years affected. Conclusions: Initial results from the STAMINA-HFP Registry suggest that anemia is a common comorbidity in unselected outpatients with heart failure. Given the strong association of anemia with adverse outcomes in heart failure, this study supports further investigation concerning the importance of anemia as a therapeutic target in this condition.

Original languageEnglish (US)
Pages (from-to)926-932
Number of pages7
JournalAmerican Heart Journal
Volume157
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

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Registries
Anemia
Heart Failure
Population
Hemoglobins
Fingers
Comorbidity
Outpatients
Quality of Life

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prospective assessment of the occurrence of anemia in patients with heart failure : Results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry. / Adams, Kirkwood F.; Patterson, John H.; Oren, Ron M.; Mehra, Mandeep R.; O'Connor, Christopher M.; Pina, Ileana L.; Miller, Alan B.; Chiong, Jun R.; Dunlap, Stephanie H.; Cotts, William G.; Felker, Gary M.; Schocken, Douglas D.; Schwartz, Todd A.; Ghali, Jalal K.

In: American Heart Journal, Vol. 157, No. 5, 05.2009, p. 926-932.

Research output: Contribution to journalArticle

Adams, KF, Patterson, JH, Oren, RM, Mehra, MR, O'Connor, CM, Pina, IL, Miller, AB, Chiong, JR, Dunlap, SH, Cotts, WG, Felker, GM, Schocken, DD, Schwartz, TA & Ghali, JK 2009, 'Prospective assessment of the occurrence of anemia in patients with heart failure: Results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry', American Heart Journal, vol. 157, no. 5, pp. 926-932. https://doi.org/10.1016/j.ahj.2009.01.012
Adams, Kirkwood F. ; Patterson, John H. ; Oren, Ron M. ; Mehra, Mandeep R. ; O'Connor, Christopher M. ; Pina, Ileana L. ; Miller, Alan B. ; Chiong, Jun R. ; Dunlap, Stephanie H. ; Cotts, William G. ; Felker, Gary M. ; Schocken, Douglas D. ; Schwartz, Todd A. ; Ghali, Jalal K. / Prospective assessment of the occurrence of anemia in patients with heart failure : Results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry. In: American Heart Journal. 2009 ; Vol. 157, No. 5. pp. 926-932.
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abstract = "Background: Although a potentially important pathophysiologic factor in heart failure, the prevalence and predictors of anemia have not been well studied in unselected patients with heart failure. Methods: The Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry prospectively studied the prevalence of anemia and the relationship of hemoglobin to health-related quality of life and outcomes among patients with heart failure. A random selection algorithm was used to reduce bias during enrollment of patients seen in specialty clinics or clinics of community cardiologists with experience in heart failure. In this initial report, data on prevalence and correlates of anemia were analyzed in 1,076 of the 1,082 registry patients who had clinical characteristics and hemoglobin determined by finger-stick at baseline. Results: Overall (n = 1,082), the registry patients were 41{\%} female and 73{\%} white with a mean age (±SD) of 64 ± 14 years (68 ± 13 years in community and 57 ± 14 years in specialty sites, P < .001). Among the 1,076 patients in the prevalence analysis, mean hemoglobin was 13.3 ± 2.1 g/dL (median 13.2 g/dL); and anemia (defined by World Health Organization criteria) was present in 34{\%}. Age identified patients at risk for anemia, with 40{\%} of patients >70 years affected. Conclusions: Initial results from the STAMINA-HFP Registry suggest that anemia is a common comorbidity in unselected outpatients with heart failure. Given the strong association of anemia with adverse outcomes in heart failure, this study supports further investigation concerning the importance of anemia as a therapeutic target in this condition.",
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T2 - Results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry

AU - Adams, Kirkwood F.

AU - Patterson, John H.

AU - Oren, Ron M.

AU - Mehra, Mandeep R.

AU - O'Connor, Christopher M.

AU - Pina, Ileana L.

AU - Miller, Alan B.

AU - Chiong, Jun R.

AU - Dunlap, Stephanie H.

AU - Cotts, William G.

AU - Felker, Gary M.

AU - Schocken, Douglas D.

AU - Schwartz, Todd A.

AU - Ghali, Jalal K.

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N2 - Background: Although a potentially important pathophysiologic factor in heart failure, the prevalence and predictors of anemia have not been well studied in unselected patients with heart failure. Methods: The Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry prospectively studied the prevalence of anemia and the relationship of hemoglobin to health-related quality of life and outcomes among patients with heart failure. A random selection algorithm was used to reduce bias during enrollment of patients seen in specialty clinics or clinics of community cardiologists with experience in heart failure. In this initial report, data on prevalence and correlates of anemia were analyzed in 1,076 of the 1,082 registry patients who had clinical characteristics and hemoglobin determined by finger-stick at baseline. Results: Overall (n = 1,082), the registry patients were 41% female and 73% white with a mean age (±SD) of 64 ± 14 years (68 ± 13 years in community and 57 ± 14 years in specialty sites, P < .001). Among the 1,076 patients in the prevalence analysis, mean hemoglobin was 13.3 ± 2.1 g/dL (median 13.2 g/dL); and anemia (defined by World Health Organization criteria) was present in 34%. Age identified patients at risk for anemia, with 40% of patients >70 years affected. Conclusions: Initial results from the STAMINA-HFP Registry suggest that anemia is a common comorbidity in unselected outpatients with heart failure. Given the strong association of anemia with adverse outcomes in heart failure, this study supports further investigation concerning the importance of anemia as a therapeutic target in this condition.

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