ProSAAS and prohormone convertase 1 are broadly expressed during mouse development

Yun Feng; Sandra E. Reznik; Lloyd D. Fricker

doi:10.1016/S1567-133X(02)00002-9

ProSAAS and prohormone convertase 1 are broadly expressed during mouse development

Yun Feng, Sandra E. Reznik, Lloyd D. Fricker

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

ProSAAS (encoded by mouse gene Pcsk1n) is a recently described neuroendocrine secretory pathway protein that is cleaved into smaller peptides that may function in cell-cell signalling. ProSAAS and its processing intermediates are also potent inhibitors of prohormone convertase 1 (PC1), which is encoded by mouse gene Pcsk1. In order to gain insight into the function of proSAAS, we have examined the distribution of several proSAAS-derived peptides and PC1 by immunohistochemistry throughout mouse development. The distribution patterns of both SAAS and PC1 are broad from E9 to E11, with some enrichment in neural tube-derived tissues. By E15, the expression of SAAS is largely restricted to neuroendocrine tissues known to produce bioactive peptides. In general, the expression pattern of PC1 overlaps with that of SAAS and other proSAAS-derived peptides, consistent with the hypothesis that proSAAS functions as an endogenous PC1 inhibitor.

Original language	English (US)
Pages (from-to)	135-140
Number of pages	6
Journal	Brain research. Gene expression patterns
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/S1567-133X(02)00002-9
State	Published - 2002

Keywords

7B2
Carboxypeptidase E
Chromogranin A
Chromogranin B
Development
Furin
LEN
Metallocarboxypeptidase
Neuropeptide
Neuropeptide biosynthesis
PEN
Prohormone convertase 1
Prohormone convertase 2
SAAS
Secretogranin 2

ASJC Scopus subject areas

Molecular Biology
Genetics
Developmental Biology

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10.1016/S1567-133X(02)00002-9

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title = "ProSAAS and prohormone convertase 1 are broadly expressed during mouse development",

abstract = "ProSAAS (encoded by mouse gene Pcsk1n) is a recently described neuroendocrine secretory pathway protein that is cleaved into smaller peptides that may function in cell-cell signalling. ProSAAS and its processing intermediates are also potent inhibitors of prohormone convertase 1 (PC1), which is encoded by mouse gene Pcsk1. In order to gain insight into the function of proSAAS, we have examined the distribution of several proSAAS-derived peptides and PC1 by immunohistochemistry throughout mouse development. The distribution patterns of both SAAS and PC1 are broad from E9 to E11, with some enrichment in neural tube-derived tissues. By E15, the expression of SAAS is largely restricted to neuroendocrine tissues known to produce bioactive peptides. In general, the expression pattern of PC1 overlaps with that of SAAS and other proSAAS-derived peptides, consistent with the hypothesis that proSAAS functions as an endogenous PC1 inhibitor.",

keywords = "7B2, Carboxypeptidase E, Chromogranin A, Chromogranin B, Development, Furin, LEN, Metallocarboxypeptidase, Neuropeptide, Neuropeptide biosynthesis, PEN, Prohormone convertase 1, Prohormone convertase 2, SAAS, Secretogranin 2",

author = "Yun Feng and Reznik, {Sandra E.} and Fricker, {Lloyd D.}",

note = "Funding Information: This work was supported in part by National Institutes of Health grants DA-04494 and Research Scientist Development Award DA-00194 (L.D.F.) and by K08-HD-01209 (S.E.R.).",

year = "2002",

doi = "10.1016/S1567-133X(02)00002-9",

language = "English (US)",

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pages = "135--140",

journal = "Brain research. Gene expression patterns",

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AU - Feng, Yun

AU - Reznik, Sandra E.

AU - Fricker, Lloyd D.

N1 - Funding Information: This work was supported in part by National Institutes of Health grants DA-04494 and Research Scientist Development Award DA-00194 (L.D.F.) and by K08-HD-01209 (S.E.R.).

PY - 2002

Y1 - 2002

N2 - ProSAAS (encoded by mouse gene Pcsk1n) is a recently described neuroendocrine secretory pathway protein that is cleaved into smaller peptides that may function in cell-cell signalling. ProSAAS and its processing intermediates are also potent inhibitors of prohormone convertase 1 (PC1), which is encoded by mouse gene Pcsk1. In order to gain insight into the function of proSAAS, we have examined the distribution of several proSAAS-derived peptides and PC1 by immunohistochemistry throughout mouse development. The distribution patterns of both SAAS and PC1 are broad from E9 to E11, with some enrichment in neural tube-derived tissues. By E15, the expression of SAAS is largely restricted to neuroendocrine tissues known to produce bioactive peptides. In general, the expression pattern of PC1 overlaps with that of SAAS and other proSAAS-derived peptides, consistent with the hypothesis that proSAAS functions as an endogenous PC1 inhibitor.

AB - ProSAAS (encoded by mouse gene Pcsk1n) is a recently described neuroendocrine secretory pathway protein that is cleaved into smaller peptides that may function in cell-cell signalling. ProSAAS and its processing intermediates are also potent inhibitors of prohormone convertase 1 (PC1), which is encoded by mouse gene Pcsk1. In order to gain insight into the function of proSAAS, we have examined the distribution of several proSAAS-derived peptides and PC1 by immunohistochemistry throughout mouse development. The distribution patterns of both SAAS and PC1 are broad from E9 to E11, with some enrichment in neural tube-derived tissues. By E15, the expression of SAAS is largely restricted to neuroendocrine tissues known to produce bioactive peptides. In general, the expression pattern of PC1 overlaps with that of SAAS and other proSAAS-derived peptides, consistent with the hypothesis that proSAAS functions as an endogenous PC1 inhibitor.

KW - 7B2

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KW - Chromogranin B

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KW - Metallocarboxypeptidase

KW - Neuropeptide

KW - Neuropeptide biosynthesis

KW - PEN

KW - Prohormone convertase 1

KW - Prohormone convertase 2

KW - SAAS

KW - Secretogranin 2

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ProSAAS and prohormone convertase 1 are broadly expressed during mouse development

Abstract

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