Pros and Cons of Chaperone-Mediated Autophagy in Cancer Biology

Esperanza Arias, Ana Maria Cuervo

Research output: Contribution to journalReview article

Abstract

Autophagy contributes to cellular quality control and energetics through lysosomal breakdown and recycling of essential cellular components. Chaperone-mediated autophagy (CMA) adds to these autophagic functions the ability to timely and selectively degrade single tagged proteins to terminate their cellular function and, in this way, participate in the regulation of multiple cellular processes. Many cancer cells upregulate CMA for protumorigenic and prosurvival purposes. However, growing evidence supports a physiological role for CMA in limiting malignant transformation. Understanding the mechanisms behind this functional switch of CMA from antioncogenic to pro-oncogenic is fundamental for targeting CMA in cancer treatment. We summarize current understanding of CMA functions in cancer biology and discuss the basis for its context-dependent dual role in oncogenesis.

Original languageEnglish (US)
JournalTrends in Endocrinology and Metabolism
DOIs
StateAccepted/In press - Jan 1 2019

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Autophagy
Neoplasms
Recycling
Quality Control
Carcinogenesis
Up-Regulation
Proteins

Keywords

  • chaperones
  • lysosomes
  • metabolism
  • oncogenes
  • protein degradation
  • tumorigenesis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Pros and Cons of Chaperone-Mediated Autophagy in Cancer Biology. / Arias, Esperanza; Cuervo, Ana Maria.

In: Trends in Endocrinology and Metabolism, 01.01.2019.

Research output: Contribution to journalReview article

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