Proliferation kinetics of Sezary cells

J. D. Schwarzmeier, Elisabeth M. Paietta, T. Radaszkiewicz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The proliferation kinetics of neoplastic T cells arising in Sezary syndrome (Sezary cells) are still poorly understood. Kinetic studies with 3H-thymidine as a DNA precursor revealed a low incorporation rate of the nucleotide into Sezary cells obtained from the peripheral blood versus Sezary cells from the skin. Using the double-label autoradiography we determined the duration of single cell cycle phases of blood and cutaneous Sezary cells. The results indicate the almost complete lack of proliferative activity in the blood but a considerable portion of proliferatively active Sezary cells in skin infiltrates. The removal of a large mass of quiescent blood cells by leukapheresis did not affect the proliferative state of the residual peripheral cell population implying that the procedure did not induce the migration of proliferating skin cells towards the blood. Terminally, the disease underwent transition into immunoblastic lymphoma. At this time, the kinetic behavior of the peripheral immunoblasts showed great similarity to that of cutaneous Sezary cells. The findings point towards a common extravascular production site of Sezary cells and immunoblasts probably located in the lymphatic tissue.

Original languageEnglish (US)
Pages (from-to)1049-1054
Number of pages6
JournalBlood
Volume57
Issue number6
StatePublished - 1981
Externally publishedYes

Fingerprint

Blood
Cells
Kinetics
Skin
T-cells
Blood Cells
Thymidine
Sezary Syndrome
Labels
Leukapheresis
Nucleotides
Tissue
Lymphoid Tissue
Autoradiography
DNA
Lymphoma
Cell Cycle
T-Lymphocytes
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Schwarzmeier, J. D., Paietta, E. M., & Radaszkiewicz, T. (1981). Proliferation kinetics of Sezary cells. Blood, 57(6), 1049-1054.

Proliferation kinetics of Sezary cells. / Schwarzmeier, J. D.; Paietta, Elisabeth M.; Radaszkiewicz, T.

In: Blood, Vol. 57, No. 6, 1981, p. 1049-1054.

Research output: Contribution to journalArticle

Schwarzmeier, JD, Paietta, EM & Radaszkiewicz, T 1981, 'Proliferation kinetics of Sezary cells', Blood, vol. 57, no. 6, pp. 1049-1054.
Schwarzmeier JD, Paietta EM, Radaszkiewicz T. Proliferation kinetics of Sezary cells. Blood. 1981;57(6):1049-1054.
Schwarzmeier, J. D. ; Paietta, Elisabeth M. ; Radaszkiewicz, T. / Proliferation kinetics of Sezary cells. In: Blood. 1981 ; Vol. 57, No. 6. pp. 1049-1054.
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N2 - The proliferation kinetics of neoplastic T cells arising in Sezary syndrome (Sezary cells) are still poorly understood. Kinetic studies with 3H-thymidine as a DNA precursor revealed a low incorporation rate of the nucleotide into Sezary cells obtained from the peripheral blood versus Sezary cells from the skin. Using the double-label autoradiography we determined the duration of single cell cycle phases of blood and cutaneous Sezary cells. The results indicate the almost complete lack of proliferative activity in the blood but a considerable portion of proliferatively active Sezary cells in skin infiltrates. The removal of a large mass of quiescent blood cells by leukapheresis did not affect the proliferative state of the residual peripheral cell population implying that the procedure did not induce the migration of proliferating skin cells towards the blood. Terminally, the disease underwent transition into immunoblastic lymphoma. At this time, the kinetic behavior of the peripheral immunoblasts showed great similarity to that of cutaneous Sezary cells. The findings point towards a common extravascular production site of Sezary cells and immunoblasts probably located in the lymphatic tissue.

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