Prolactin and sodium lactate-induced panic

Eric Hollander, Michael R. Liebowitz, Barry Cohen, Jack M. Gorman, Abby J. Fyer, Laszlo A. Papp, Donald F. Klein

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Sodium lactate infusions reliably induce panic attacks in panic disorder patients but not in normal controls, but the mechanism underlying this response is unknown. We studied the plasma prolactin response to infusion of 0.5 molar sodium lactate in 38 patients with panic disorder or agoraphobia with panic attacks, and 16 normal controls. As expected, baseline plasma prolactin was significantly higher in female subjects than in male subjects. However, the males who experienced lactate-induced panic had significantly elevated baseline prolactin levels compared to male nonpanickers and controls. Prolactin levels increased in all groups during lactate infusion, which may reflect osmotic effects, but were blunted in the late panickers compared to nonpanickers and controls. The elevated baseline prolactin for male panickers supports a relationship between prolactin and anticipatory anxiety. The blunted prolactin response for late panickers suggests a net diminution, rather than a sensitization, of prolactin response in panic anxiety.

Original languageEnglish (US)
Pages (from-to)181-191
Number of pages11
JournalPsychiatry Research
Volume28
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Sodium Lactate
Panic
Prolactin
Panic Disorder
Lactic Acid
Anxiety
Agoraphobia

Keywords

  • agoraphobia
  • anxiety
  • panic disorder
  • Prolactin
  • sodium lactate

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Hollander, E., Liebowitz, M. R., Cohen, B., Gorman, J. M., Fyer, A. J., Papp, L. A., & Klein, D. F. (1989). Prolactin and sodium lactate-induced panic. Psychiatry Research, 28(2), 181-191. https://doi.org/10.1016/0165-1781(89)90046-2

Prolactin and sodium lactate-induced panic. / Hollander, Eric; Liebowitz, Michael R.; Cohen, Barry; Gorman, Jack M.; Fyer, Abby J.; Papp, Laszlo A.; Klein, Donald F.

In: Psychiatry Research, Vol. 28, No. 2, 1989, p. 181-191.

Research output: Contribution to journalArticle

Hollander, E, Liebowitz, MR, Cohen, B, Gorman, JM, Fyer, AJ, Papp, LA & Klein, DF 1989, 'Prolactin and sodium lactate-induced panic', Psychiatry Research, vol. 28, no. 2, pp. 181-191. https://doi.org/10.1016/0165-1781(89)90046-2
Hollander E, Liebowitz MR, Cohen B, Gorman JM, Fyer AJ, Papp LA et al. Prolactin and sodium lactate-induced panic. Psychiatry Research. 1989;28(2):181-191. https://doi.org/10.1016/0165-1781(89)90046-2
Hollander, Eric ; Liebowitz, Michael R. ; Cohen, Barry ; Gorman, Jack M. ; Fyer, Abby J. ; Papp, Laszlo A. ; Klein, Donald F. / Prolactin and sodium lactate-induced panic. In: Psychiatry Research. 1989 ; Vol. 28, No. 2. pp. 181-191.
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