Progressive transformation of germinal centers

Report of 2 cases and review of the literature

Amit K. Verma, Wendy Stock, Sandhya Norohna, Rajul Shah, Basil Bradlow, Leonidas C. Platanias

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Progressive transformation of germinal centers (PTGC) is a disease of mostly young adults that presents as unexplained, asymptomatic, localized or generalized lymphadenopathy which is usually persistent or recurrent over periods of many years. Histologically, the germinal centers contain a variable proportion of small mantle zone lymphocytes and thus become progressively transformed and may result in the loss of clear demarcation between them and the mantle zone. Here, we describe two cases of this disease and review the literature on the association of PTGC with lymphocyte-predominant Hodgkin's disease.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalActa Haematologica
Volume108
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Lymphocytes
Germinal Center
Hodgkin Disease
Young Adult
Progressive Transformation of Germinal Centers
Lymphadenopathy

Keywords

  • Germinal centers, progressive transformation
  • Hodgkin's disease, lymphocyte predominant
  • Lymphadenopathy

ASJC Scopus subject areas

  • Hematology

Cite this

Progressive transformation of germinal centers : Report of 2 cases and review of the literature. / Verma, Amit K.; Stock, Wendy; Norohna, Sandhya; Shah, Rajul; Bradlow, Basil; Platanias, Leonidas C.

In: Acta Haematologica, Vol. 108, No. 1, 2002, p. 33-38.

Research output: Contribution to journalArticle

Verma, Amit K. ; Stock, Wendy ; Norohna, Sandhya ; Shah, Rajul ; Bradlow, Basil ; Platanias, Leonidas C. / Progressive transformation of germinal centers : Report of 2 cases and review of the literature. In: Acta Haematologica. 2002 ; Vol. 108, No. 1. pp. 33-38.
@article{eb59235c5e554812b00d1dda65b401be,
title = "Progressive transformation of germinal centers: Report of 2 cases and review of the literature",
abstract = "Progressive transformation of germinal centers (PTGC) is a disease of mostly young adults that presents as unexplained, asymptomatic, localized or generalized lymphadenopathy which is usually persistent or recurrent over periods of many years. Histologically, the germinal centers contain a variable proportion of small mantle zone lymphocytes and thus become progressively transformed and may result in the loss of clear demarcation between them and the mantle zone. Here, we describe two cases of this disease and review the literature on the association of PTGC with lymphocyte-predominant Hodgkin's disease.",
keywords = "Germinal centers, progressive transformation, Hodgkin's disease, lymphocyte predominant, Lymphadenopathy",
author = "Verma, {Amit K.} and Wendy Stock and Sandhya Norohna and Rajul Shah and Basil Bradlow and Platanias, {Leonidas C.}",
year = "2002",
doi = "10.1159/000063057",
language = "English (US)",
volume = "108",
pages = "33--38",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Progressive transformation of germinal centers

T2 - Report of 2 cases and review of the literature

AU - Verma, Amit K.

AU - Stock, Wendy

AU - Norohna, Sandhya

AU - Shah, Rajul

AU - Bradlow, Basil

AU - Platanias, Leonidas C.

PY - 2002

Y1 - 2002

N2 - Progressive transformation of germinal centers (PTGC) is a disease of mostly young adults that presents as unexplained, asymptomatic, localized or generalized lymphadenopathy which is usually persistent or recurrent over periods of many years. Histologically, the germinal centers contain a variable proportion of small mantle zone lymphocytes and thus become progressively transformed and may result in the loss of clear demarcation between them and the mantle zone. Here, we describe two cases of this disease and review the literature on the association of PTGC with lymphocyte-predominant Hodgkin's disease.

AB - Progressive transformation of germinal centers (PTGC) is a disease of mostly young adults that presents as unexplained, asymptomatic, localized or generalized lymphadenopathy which is usually persistent or recurrent over periods of many years. Histologically, the germinal centers contain a variable proportion of small mantle zone lymphocytes and thus become progressively transformed and may result in the loss of clear demarcation between them and the mantle zone. Here, we describe two cases of this disease and review the literature on the association of PTGC with lymphocyte-predominant Hodgkin's disease.

KW - Germinal centers, progressive transformation

KW - Hodgkin's disease, lymphocyte predominant

KW - Lymphadenopathy

UR - http://www.scopus.com/inward/record.url?scp=0036361921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036361921&partnerID=8YFLogxK

U2 - 10.1159/000063057

DO - 10.1159/000063057

M3 - Article

VL - 108

SP - 33

EP - 38

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 1

ER -