Progress and prospects of anti-HBV gene therapy development

Mohube B. Maepa, Ilke Roelofse, Abdullah Ely, Patrick Arbuthnot

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Despite the availability of an effective vaccine against hepatitis B virus (HBV), chronic infection with the virus remains a major global health concern. Current drugs against HBV infection are limited by emergence of resistance and rarely achieve complete viral clearance. This has prompted vigorous research on developing better drugs against chronic HBV infection. Advances in understanding the life cycle of HBV and improvements in gene-disabling technologies have been impressive. This has led to development of better HBV infection models and discovery of new drug candidates. Ideally, a regimen against chronic HBV infection should completely eliminate all viral replicative intermediates, especially covalently closed circular DNA (cccDNA). For the past few decades, nucleic acid-based therapy has emerged as an attractive alternative that may result in complete clearance of HBV in infected patients. Several genetic anti-HBV strategies have been developed. The most studied approaches include the use of antisense oligonucleotides, ribozymes, RNA interference effectors and gene editing tools. This review will summarize recent developments and progress made in the use of gene therapy against HBV.

Original languageEnglish (US)
Pages (from-to)17589-17610
Number of pages22
JournalInternational Journal of Molecular Sciences
Volume16
Issue number8
DOIs
StatePublished - Jul 31 2015
Externally publishedYes

Keywords

  • Antisense oligonucleotides
  • Gene editing
  • Gene therapy
  • HBV
  • RNAi
  • Ribozymes

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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