Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia

A. Gradíssimo Oliveira, C. Delgado, N. Verdasca, Â Pista

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.

Original languageEnglish (US)
Pages (from-to)E447-E450
JournalClinical Microbiology and Infection
Volume19
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • Cervical cancer
  • Human papillomavirus 18
  • Molecular marker
  • Physical status
  • Risk assessment

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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