Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

Adolfo A. Ferrando, Donna S. Neuberg, Richard K. Dodge, Elisabeth M. Paietta, Richard A. Larson, Peter H. Wiernik, Jacob M. Rowe, Michael A. Caligiuri, Clara D. Bloomfield, A. Thomas Look

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors - TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2 - in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.

Original languageEnglish (US)
Pages (from-to)535-536
Number of pages2
JournalLancet
Volume363
Issue number9408
DOIs
StatePublished - Feb 14 2004
Externally publishedYes

Fingerprint

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Oncogenes
Leukemia
Transcription Factors
T-Lymphocyte Subsets
Stem Cell Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survival Rate
Survival
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ferrando, A. A., Neuberg, D. S., Dodge, R. K., Paietta, E. M., Larson, R. A., Wiernik, P. H., ... Look, A. T. (2004). Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. Lancet, 363(9408), 535-536. https://doi.org/10.1016/S0140-6736(04)15542-6

Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. / Ferrando, Adolfo A.; Neuberg, Donna S.; Dodge, Richard K.; Paietta, Elisabeth M.; Larson, Richard A.; Wiernik, Peter H.; Rowe, Jacob M.; Caligiuri, Michael A.; Bloomfield, Clara D.; Look, A. Thomas.

In: Lancet, Vol. 363, No. 9408, 14.02.2004, p. 535-536.

Research output: Contribution to journalArticle

Ferrando, AA, Neuberg, DS, Dodge, RK, Paietta, EM, Larson, RA, Wiernik, PH, Rowe, JM, Caligiuri, MA, Bloomfield, CD & Look, AT 2004, 'Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia', Lancet, vol. 363, no. 9408, pp. 535-536. https://doi.org/10.1016/S0140-6736(04)15542-6
Ferrando, Adolfo A. ; Neuberg, Donna S. ; Dodge, Richard K. ; Paietta, Elisabeth M. ; Larson, Richard A. ; Wiernik, Peter H. ; Rowe, Jacob M. ; Caligiuri, Michael A. ; Bloomfield, Clara D. ; Look, A. Thomas. / Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. In: Lancet. 2004 ; Vol. 363, No. 9408. pp. 535-536.
@article{aa78334f778b41db9c1d6a0dcaba29d3,
title = "Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia",
abstract = "The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors - TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2 - in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88{\%} (90{\%} CI 73-100{\%}), compared with 56{\%} (42-70{\%}) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.",
author = "Ferrando, {Adolfo A.} and Neuberg, {Donna S.} and Dodge, {Richard K.} and Paietta, {Elisabeth M.} and Larson, {Richard A.} and Wiernik, {Peter H.} and Rowe, {Jacob M.} and Caligiuri, {Michael A.} and Bloomfield, {Clara D.} and Look, {A. Thomas}",
year = "2004",
month = "2",
day = "14",
doi = "10.1016/S0140-6736(04)15542-6",
language = "English (US)",
volume = "363",
pages = "535--536",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "9408",

}

TY - JOUR

T1 - Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

AU - Ferrando, Adolfo A.

AU - Neuberg, Donna S.

AU - Dodge, Richard K.

AU - Paietta, Elisabeth M.

AU - Larson, Richard A.

AU - Wiernik, Peter H.

AU - Rowe, Jacob M.

AU - Caligiuri, Michael A.

AU - Bloomfield, Clara D.

AU - Look, A. Thomas

PY - 2004/2/14

Y1 - 2004/2/14

N2 - The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors - TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2 - in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.

AB - The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors - TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2 - in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.

UR - http://www.scopus.com/inward/record.url?scp=10744222734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744222734&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(04)15542-6

DO - 10.1016/S0140-6736(04)15542-6

M3 - Article

C2 - 14975618

AN - SCOPUS:10744222734

VL - 363

SP - 535

EP - 536

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9408

ER -