Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

Adolfo A. Ferrando; Donna S. Neuberg; Richard K. Dodge; Elisabeth Paietta; Richard A. Larson; Peter H. Wiernik; Jacob M. Rowe; Michael A. Caligiuri; Clara D. Bloomfield; A. Thomas Look

doi:10.1016/S0140-6736(04)15542-6

Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

Adolfo A. Ferrando, Donna S. Neuberg, Richard K. Dodge, Elisabeth Paietta, Richard A. Larson, Peter H. Wiernik, Jacob M. Rowe, Michael A. Caligiuri, Clara D. Bloomfield, A. Thomas Look

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors - TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2 - in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.

Original language	English (US)
Pages (from-to)	535-536
Number of pages	2
Journal	Lancet
Volume	363
Issue number	9408
DOIs	https://doi.org/10.1016/S0140-6736(04)15542-6
State	Published - Feb 14 2004
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. / Ferrando, Adolfo A.; Neuberg, Donna S.; Dodge, Richard K.; Paietta, Elisabeth; Larson, Richard A.; Wiernik, Peter H.; Rowe, Jacob M.; Caligiuri, Michael A.; Bloomfield, Clara D.; Look, A. Thomas.

In: Lancet, Vol. 363, No. 9408, 14.02.2004, p. 535-536.

Research output: Contribution to journal › Article › peer-review

Ferrando, Adolfo A. ; Neuberg, Donna S. ; Dodge, Richard K. ; Paietta, Elisabeth ; Larson, Richard A. ; Wiernik, Peter H. ; Rowe, Jacob M. ; Caligiuri, Michael A. ; Bloomfield, Clara D. ; Look, A. Thomas. / Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. In: Lancet. 2004 ; Vol. 363, No. 9408. pp. 535-536.

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title = "Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia",

abstract = "The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors - TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2 - in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.",

author = "Ferrando, {Adolfo A.} and Neuberg, {Donna S.} and Dodge, {Richard K.} and Elisabeth Paietta and Larson, {Richard A.} and Wiernik, {Peter H.} and Rowe, {Jacob M.} and Caligiuri, {Michael A.} and Bloomfield, {Clara D.} and Look, {A. Thomas}",

note = "Funding Information: This work was supported by the following grants: CA16058, CA77658, CA31946, CA23318, CA21115, CA101140, and the Leukemia Clinical Research Foundation. Adolfo A Ferrando is a fellow of the Leukemia and Lymphoma Society. A Thomas Look had full access to the data in the study and had the final responsibility for the decision to submit for publication. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2004",

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doi = "10.1016/S0140-6736(04)15542-6",

language = "English (US)",

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T1 - Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

AU - Ferrando, Adolfo A.

AU - Neuberg, Donna S.

AU - Dodge, Richard K.

AU - Paietta, Elisabeth

AU - Larson, Richard A.

AU - Wiernik, Peter H.

AU - Rowe, Jacob M.

AU - Caligiuri, Michael A.

AU - Bloomfield, Clara D.

AU - Look, A. Thomas

N1 - Funding Information: This work was supported by the following grants: CA16058, CA77658, CA31946, CA23318, CA21115, CA101140, and the Leukemia Clinical Research Foundation. Adolfo A Ferrando is a fellow of the Leukemia and Lymphoma Society. A Thomas Look had full access to the data in the study and had the final responsibility for the decision to submit for publication. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2004/2/14

Y1 - 2004/2/14

N2 - The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors - TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2 - in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.

AB - The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors - TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2 - in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.

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ER -

Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

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