Prognostic factors and outcomes for osteosarcoma

An international collaboration

Emilios E. Pakos, Andreas D. Nearchou, Robert J. Grimer, Haris D. Koumoullis, Adesegun Abudu, Jos A M Bramer, Lee M. Jeys, Alessandro Franchi, Guido Scoccianti, Domenico Campanacci, Rodolfo Capanna, Jorge Aparicio, Marie Dominique Tabone, Gerold Holzer, Fashid Abdolvahab, Philipp Funovics, Martin Dominkus, Inci Ilhan, Su G. Berrak, Ana Patino-Garcia & 11 others Luis Sierrasesumaga, Mikel San-Julian, Moira Garraus, Antonio Sergio Petrilli, Reynaldo Jesus Garcia Filho, Carla Renata Pacheco Donato Macedo, Maria Teresa de Seixas Alves, Sven Seiwerth, Rajaram Nagarajan, Timothy P. Cripe, John P A Ioannidis

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

We aimed to evaluate the prognostic significance of traditional clinical predictors in osteosarcoma through an international collaboration of 10 teams of investigators (2680 patients) who participated. In multivariate models the mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate. It was also influenced by the site of the tumour. The risk of metastasis increased when metastatic disease was present at the time the patient was first seen and also increased with use of amputation or unusual treatment combinations or chemotherapy regimens not including anthracycline and platinum. Local recurrence risk was higher in older patients, in those who had local recurrence when first seen and when no anthracycline and platinum were used in chemotherapy. Results were similar when limited to patients seen after 1990 and treated with surgery plus combination chemotherapy. This large-scale international collaboration identifies strong predictors of major clinical outcomes in osteosarcoma.

Original languageEnglish (US)
Pages (from-to)2367-2375
Number of pages9
JournalEuropean Journal of Cancer
Volume45
Issue number13
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Osteosarcoma
Anthracyclines
Platinum
Combination Drug Therapy
Amputation
Recurrence
Limb Salvage
Methotrexate
Research Personnel
Neoplasm Metastasis
Drug Therapy
Mortality
Therapeutics
Neoplasms

Keywords

  • Clinical predictors
  • International collaboration
  • Metastasis
  • Osteosarcoma
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pakos, E. E., Nearchou, A. D., Grimer, R. J., Koumoullis, H. D., Abudu, A., Bramer, J. A. M., ... Ioannidis, J. P. A. (2009). Prognostic factors and outcomes for osteosarcoma: An international collaboration. European Journal of Cancer, 45(13), 2367-2375. https://doi.org/10.1016/j.ejca.2009.03.005

Prognostic factors and outcomes for osteosarcoma : An international collaboration. / Pakos, Emilios E.; Nearchou, Andreas D.; Grimer, Robert J.; Koumoullis, Haris D.; Abudu, Adesegun; Bramer, Jos A M; Jeys, Lee M.; Franchi, Alessandro; Scoccianti, Guido; Campanacci, Domenico; Capanna, Rodolfo; Aparicio, Jorge; Tabone, Marie Dominique; Holzer, Gerold; Abdolvahab, Fashid; Funovics, Philipp; Dominkus, Martin; Ilhan, Inci; Berrak, Su G.; Patino-Garcia, Ana; Sierrasesumaga, Luis; San-Julian, Mikel; Garraus, Moira; Petrilli, Antonio Sergio; Filho, Reynaldo Jesus Garcia; Macedo, Carla Renata Pacheco Donato; Alves, Maria Teresa de Seixas; Seiwerth, Sven; Nagarajan, Rajaram; Cripe, Timothy P.; Ioannidis, John P A.

In: European Journal of Cancer, Vol. 45, No. 13, 09.2009, p. 2367-2375.

Research output: Contribution to journalArticle

Pakos, EE, Nearchou, AD, Grimer, RJ, Koumoullis, HD, Abudu, A, Bramer, JAM, Jeys, LM, Franchi, A, Scoccianti, G, Campanacci, D, Capanna, R, Aparicio, J, Tabone, MD, Holzer, G, Abdolvahab, F, Funovics, P, Dominkus, M, Ilhan, I, Berrak, SG, Patino-Garcia, A, Sierrasesumaga, L, San-Julian, M, Garraus, M, Petrilli, AS, Filho, RJG, Macedo, CRPD, Alves, MTDS, Seiwerth, S, Nagarajan, R, Cripe, TP & Ioannidis, JPA 2009, 'Prognostic factors and outcomes for osteosarcoma: An international collaboration', European Journal of Cancer, vol. 45, no. 13, pp. 2367-2375. https://doi.org/10.1016/j.ejca.2009.03.005
Pakos EE, Nearchou AD, Grimer RJ, Koumoullis HD, Abudu A, Bramer JAM et al. Prognostic factors and outcomes for osteosarcoma: An international collaboration. European Journal of Cancer. 2009 Sep;45(13):2367-2375. https://doi.org/10.1016/j.ejca.2009.03.005
Pakos, Emilios E. ; Nearchou, Andreas D. ; Grimer, Robert J. ; Koumoullis, Haris D. ; Abudu, Adesegun ; Bramer, Jos A M ; Jeys, Lee M. ; Franchi, Alessandro ; Scoccianti, Guido ; Campanacci, Domenico ; Capanna, Rodolfo ; Aparicio, Jorge ; Tabone, Marie Dominique ; Holzer, Gerold ; Abdolvahab, Fashid ; Funovics, Philipp ; Dominkus, Martin ; Ilhan, Inci ; Berrak, Su G. ; Patino-Garcia, Ana ; Sierrasesumaga, Luis ; San-Julian, Mikel ; Garraus, Moira ; Petrilli, Antonio Sergio ; Filho, Reynaldo Jesus Garcia ; Macedo, Carla Renata Pacheco Donato ; Alves, Maria Teresa de Seixas ; Seiwerth, Sven ; Nagarajan, Rajaram ; Cripe, Timothy P. ; Ioannidis, John P A. / Prognostic factors and outcomes for osteosarcoma : An international collaboration. In: European Journal of Cancer. 2009 ; Vol. 45, No. 13. pp. 2367-2375.
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