TY - JOUR
T1 - Prognostic factors and outcomes for osteosarcoma
T2 - An international collaboration
AU - Pakos, Emilios E.
AU - Nearchou, Andreas D.
AU - Grimer, Robert J.
AU - Koumoullis, Haris D.
AU - Abudu, Adesegun
AU - Bramer, Jos A.M.
AU - Jeys, Lee M.
AU - Franchi, Alessandro
AU - Scoccianti, Guido
AU - Campanacci, Domenico
AU - Capanna, Rodolfo
AU - Aparicio, Jorge
AU - Tabone, Marie Dominique
AU - Holzer, Gerold
AU - Abdolvahab, Fashid
AU - Funovics, Philipp
AU - Dominkus, Martin
AU - Ilhan, Inci
AU - Berrak, Su G.
AU - Patino-Garcia, Ana
AU - Sierrasesumaga, Luis
AU - San-Julian, Mikel
AU - Garraus, Moira
AU - Petrilli, Antonio Sergio
AU - Filho, Reynaldo Jesus Garcia
AU - Macedo, Carla Renata Pacheco Donato
AU - Alves, Maria Teresa de Seixas
AU - Seiwerth, Sven
AU - Nagarajan, Rajaram
AU - Cripe, Timothy P.
AU - Ioannidis, John P.A.
PY - 2009/9
Y1 - 2009/9
N2 - We aimed to evaluate the prognostic significance of traditional clinical predictors in osteosarcoma through an international collaboration of 10 teams of investigators (2680 patients) who participated. In multivariate models the mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate. It was also influenced by the site of the tumour. The risk of metastasis increased when metastatic disease was present at the time the patient was first seen and also increased with use of amputation or unusual treatment combinations or chemotherapy regimens not including anthracycline and platinum. Local recurrence risk was higher in older patients, in those who had local recurrence when first seen and when no anthracycline and platinum were used in chemotherapy. Results were similar when limited to patients seen after 1990 and treated with surgery plus combination chemotherapy. This large-scale international collaboration identifies strong predictors of major clinical outcomes in osteosarcoma.
AB - We aimed to evaluate the prognostic significance of traditional clinical predictors in osteosarcoma through an international collaboration of 10 teams of investigators (2680 patients) who participated. In multivariate models the mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate. It was also influenced by the site of the tumour. The risk of metastasis increased when metastatic disease was present at the time the patient was first seen and also increased with use of amputation or unusual treatment combinations or chemotherapy regimens not including anthracycline and platinum. Local recurrence risk was higher in older patients, in those who had local recurrence when first seen and when no anthracycline and platinum were used in chemotherapy. Results were similar when limited to patients seen after 1990 and treated with surgery plus combination chemotherapy. This large-scale international collaboration identifies strong predictors of major clinical outcomes in osteosarcoma.
KW - Clinical predictors
KW - International collaboration
KW - Metastasis
KW - Osteosarcoma
KW - Prognosis
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=68949192290&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68949192290&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2009.03.005
DO - 10.1016/j.ejca.2009.03.005
M3 - Article
C2 - 19349163
AN - SCOPUS:68949192290
SN - 0959-8049
VL - 45
SP - 2367
EP - 2375
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 13
ER -