TY - JOUR
T1 - Progenitor cell biology
T2 - Implications for neural regeneration
AU - Mehler, Mark F.
AU - Kessler, John A.
PY - 1999/7
Y1 - 1999/7
N2 - A few brief years ago, damage to the central nervous system was generally perceived to be irreparable, and loss of neurons was largely viewed as an irreversible process. However, major advances in the study of neural progenitor cells have altered these perceptions, and rational approaches to the repair of the damaged nervous system using transplanted progenitor cells now seem feasible. This review will discuss the basic biology of neural progenitor cells, the mechanisms regulating the generation of neurons and glia from these cells, and the techniques that are available for preparing such cells for transplantation into the nervous system. The potential uses for these cells in treating neurologic disease will then be reviewed, and the theoretical and technical problems that may be encountered will be discussed.
AB - A few brief years ago, damage to the central nervous system was generally perceived to be irreparable, and loss of neurons was largely viewed as an irreversible process. However, major advances in the study of neural progenitor cells have altered these perceptions, and rational approaches to the repair of the damaged nervous system using transplanted progenitor cells now seem feasible. This review will discuss the basic biology of neural progenitor cells, the mechanisms regulating the generation of neurons and glia from these cells, and the techniques that are available for preparing such cells for transplantation into the nervous system. The potential uses for these cells in treating neurologic disease will then be reviewed, and the theoretical and technical problems that may be encountered will be discussed.
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U2 - 10.1001/archneur.56.7.780
DO - 10.1001/archneur.56.7.780
M3 - Review article
C2 - 10404978
AN - SCOPUS:0032984596
SN - 0003-9942
VL - 56
SP - 780
EP - 784
JO - Archives of Neurology
JF - Archives of Neurology
IS - 7
ER -