Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma

L. W. Stanton, J. Q. Yang, L. A. Eckhardt, L. J. Harris, B. K. Birshtein, K. B. Marcu

Research output: Contribution to journalArticle

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Abstract

The structures of the rearranged c-myc gene products derived from a rcp T(12;15) have been investigated in the MPC-11 (IgG2bκ) plasmacytoma. The rcp T(2;15) in MPC-11 is a reciprocal exchange between the c-myc gene on chromosome 15 and the immunoglobulin γ2a switch region (S(γ2a) on chromosome 12. The c-myc gene is broken within a 5'-nontranslated exon, thereby separating the promoter region of the normal c-myc gene from its protein coding sequences. This reciprocal rearrangement results in the loss of 11 base pairs of c-myc sequence and 300 base pairs of S(γ2a) sequence at the point of recombination. Sequences that represent the promoter region of the normal c-myc gene are present in the 5'-myc reciprocal fragment. A comparison of the nucleotide sequences at the recombination site of a c-myc rearrangement reveals a common feature that may have mechanistic importance for these translocation events.

Original languageEnglish (US)
Pages (from-to)829-833
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number3 I
StatePublished - 1984
Externally publishedYes

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myc Genes
Plasmacytoma
Chromosomes
Genetic Promoter Regions
Base Pairing
Immunoglobulin Switch Region
Genetic Recombination
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 12
Exons
Proteins

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Stanton, L. W., Yang, J. Q., Eckhardt, L. A., Harris, L. J., Birshtein, B. K., & Marcu, K. B. (1984). Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma. Proceedings of the National Academy of Sciences of the United States of America, 81(3 I), 829-833.

Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma. / Stanton, L. W.; Yang, J. Q.; Eckhardt, L. A.; Harris, L. J.; Birshtein, B. K.; Marcu, K. B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, No. 3 I, 1984, p. 829-833.

Research output: Contribution to journalArticle

Stanton, L. W. ; Yang, J. Q. ; Eckhardt, L. A. ; Harris, L. J. ; Birshtein, B. K. ; Marcu, K. B. / Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma. In: Proceedings of the National Academy of Sciences of the United States of America. 1984 ; Vol. 81, No. 3 I. pp. 829-833.
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