Product of per locus of drosophila shares homology with proteoglycans

F. Rob Jackson, Thaddeus A. Bargiello, Suk Hyeon Yun, Michael W. Young

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Genes controlling biological rhythms have been identified in Drosophila1,2. The best characterized of these genes is called period (per). Although wild-type flies have daily (circadian) rhythms with a periodicity of ~24 h, pers and perl mutants have 19-h and 29-h rhythms, respectively, and per0 mutants are arrhythmic 1. The pers mutation also enhances the sensitivity of the circadian clock to resetting by light stimuli3, and all three types of per mutations affect a much shorter period ultradian rhythm, the 55-s rhythm of the Drosophila courtship song4. A fragment of DNA of ~7 kilobases (kb) encoding a 4.5-kb poly(A)+ RNA restores rhyth-micity when transduced into Drosophila carrying mutations5,6 or chromosomal deletions5 of the per locus. Here we report the sequence of this biologically active segment of DNA. The transcription unit that encodes the 4.5-kb RNA has been mapped, permitting a conceptual translation of a protein of 1,127 amino acids. Several abnormal phenotypes characterized by long-period rhythms are associated with changes in the sequence of untranslated portions of the transcription unit. The structure of some segments of the predicted protein suggests that it is a proteoglycan.

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalNature
Volume320
Issue number6058
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Periodicity
Proteoglycans
Drosophila
Courtship
Mutation
Circadian Clocks
DNA
Protein Biosynthesis
Circadian Rhythm
Diptera
Genes
RNA
Phenotype
Light
Amino Acids
Messenger RNA
Proteins
Ultradian Rhythm

ASJC Scopus subject areas

  • General

Cite this

Jackson, F. R., Bargiello, T. A., Yun, S. H., & Young, M. W. (1986). Product of per locus of drosophila shares homology with proteoglycans. Nature, 320(6058), 185-188. https://doi.org/10.1038/320185a0

Product of per locus of drosophila shares homology with proteoglycans. / Jackson, F. Rob; Bargiello, Thaddeus A.; Yun, Suk Hyeon; Young, Michael W.

In: Nature, Vol. 320, No. 6058, 1986, p. 185-188.

Research output: Contribution to journalArticle

Jackson, FR, Bargiello, TA, Yun, SH & Young, MW 1986, 'Product of per locus of drosophila shares homology with proteoglycans', Nature, vol. 320, no. 6058, pp. 185-188. https://doi.org/10.1038/320185a0
Jackson FR, Bargiello TA, Yun SH, Young MW. Product of per locus of drosophila shares homology with proteoglycans. Nature. 1986;320(6058):185-188. https://doi.org/10.1038/320185a0
Jackson, F. Rob ; Bargiello, Thaddeus A. ; Yun, Suk Hyeon ; Young, Michael W. / Product of per locus of drosophila shares homology with proteoglycans. In: Nature. 1986 ; Vol. 320, No. 6058. pp. 185-188.
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