Procedure for minimizing stress for fMRI studies in conscious rats

Jean A. King; Timothy S. Garelick; Mathew E. Brevard; Wei Chen; Tara L. Messenger; Timothy Q. Duong; Craig F. Ferris

doi:10.1016/j.jneumeth.2005.04.011

Procedure for minimizing stress for fMRI studies in conscious rats

Jean A. King, Timothy S. Garelick, Mathew E. Brevard, Wei Chen, Tara L. Messenger, Timothy Q. Duong, Craig F. Ferris

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) in conscious animals is evolving as a critical tool for neuroscientists. The present study explored the effectiveness of an acclimation procedure in minimizing the stress experienced by the animal as assessed by alterations in physiological parameters including heart rate, respiratory rate, and serum corticosterone levels. Results confirm that as the stress of the protocol is minimized, there is a significant decrease in head movements and enhancement in data quality. The feasibility of improving the quality of fMRI data acquired in alert rats by utilizing a relatively simple technique is presented.

Original language	English (US)
Pages (from-to)	154-160
Number of pages	7
Journal	Journal of Neuroscience Methods
Volume	148
Issue number	2
DOIs	https://doi.org/10.1016/j.jneumeth.2005.04.011
State	Published - Oct 30 2005
Externally published	Yes

Keywords

Blood pressure
HPA axis
Heart rate
Imaging
Restraint stress
fMRI

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.jneumeth.2005.04.011

Cite this

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title = "Procedure for minimizing stress for fMRI studies in conscious rats",

abstract = "Functional magnetic resonance imaging (fMRI) in conscious animals is evolving as a critical tool for neuroscientists. The present study explored the effectiveness of an acclimation procedure in minimizing the stress experienced by the animal as assessed by alterations in physiological parameters including heart rate, respiratory rate, and serum corticosterone levels. Results confirm that as the stress of the protocol is minimized, there is a significant decrease in head movements and enhancement in data quality. The feasibility of improving the quality of fMRI data acquired in alert rats by utilizing a relatively simple technique is presented.",

keywords = "Blood pressure, HPA axis, Heart rate, Imaging, Restraint stress, fMRI",

author = "King, {Jean A.} and Garelick, {Timothy S.} and Brevard, {Mathew E.} and Wei Chen and Messenger, {Tara L.} and Duong, {Timothy Q.} and Ferris, {Craig F.}",

note = "Funding Information: We would like to acknowledge grant support for J. King (NIMH-MH 067096).",

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T1 - Procedure for minimizing stress for fMRI studies in conscious rats

AU - King, Jean A.

AU - Garelick, Timothy S.

AU - Brevard, Mathew E.

AU - Chen, Wei

AU - Messenger, Tara L.

AU - Duong, Timothy Q.

AU - Ferris, Craig F.

N1 - Funding Information: We would like to acknowledge grant support for J. King (NIMH-MH 067096).

PY - 2005/10/30

Y1 - 2005/10/30

N2 - Functional magnetic resonance imaging (fMRI) in conscious animals is evolving as a critical tool for neuroscientists. The present study explored the effectiveness of an acclimation procedure in minimizing the stress experienced by the animal as assessed by alterations in physiological parameters including heart rate, respiratory rate, and serum corticosterone levels. Results confirm that as the stress of the protocol is minimized, there is a significant decrease in head movements and enhancement in data quality. The feasibility of improving the quality of fMRI data acquired in alert rats by utilizing a relatively simple technique is presented.

AB - Functional magnetic resonance imaging (fMRI) in conscious animals is evolving as a critical tool for neuroscientists. The present study explored the effectiveness of an acclimation procedure in minimizing the stress experienced by the animal as assessed by alterations in physiological parameters including heart rate, respiratory rate, and serum corticosterone levels. Results confirm that as the stress of the protocol is minimized, there is a significant decrease in head movements and enhancement in data quality. The feasibility of improving the quality of fMRI data acquired in alert rats by utilizing a relatively simple technique is presented.

KW - Blood pressure

KW - HPA axis

KW - Heart rate

KW - Imaging

KW - Restraint stress

KW - fMRI

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Procedure for minimizing stress for fMRI studies in conscious rats

Abstract

Keywords

ASJC Scopus subject areas

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