TY - JOUR
T1 - Procedural outcomes of patients with calcified lesions treated with bioresorbable vascular scaffolds
AU - Panoulas, Vasileios F.
AU - Miyazaki, Tadashi
AU - Sato, Katsumasa
AU - Naganuma, Toru
AU - Sticchi, Alessandro
AU - Kawamoto, Hiroyoshi
AU - Figini, Filippo
AU - Chieffo, Alaide
AU - Carlino, Mauro
AU - Montorfano, Matteo
AU - Latib, Azeem
AU - Colombo, Antonio
N1 - Publisher Copyright:
© Europa Digital & Publishing 2016. All rights reserved.
PY - 2016/3
Y1 - 2016/3
N2 - Aims: To compare the feasibility, procedural and clinical outcomes after implantation of bioresorbable vascular scaffolds (BVS) in patients with calcified lesions. Methods and results: We assessed the feasibility of BVS implantation and procedural outcomes in patients with and without calcific lesions. The primary outcome was angiographic and procedural success. Secondary outcomes included major adverse cardiovascular events (MACE). Of 163 patients, 62 (38%) had calcified lesions. Patients with calcific lesions had a higher prevalence of diabetes (35.5% vs. 22.8%, p=0.078) and chronic kidney disease (31.1% vs. 13.9%, p=0.008), and higher SYNTAX scores (18.9 ±9.7 vs. 15.1 ±9.0, p=0.017). Calcific lesions required longer procedures (126.4 ±39.8 vs. 106.9 ±37.1 min, p=0.015), more frequent use of dedicated devices and IVUS. Acute gain (1.83 ±0.6 vs. 1.86 ±0.6, p=0.732) and angiographic success were similar (98% non-calcific vs. 95.2% calcific, p=0.369), whereas procedural success was reduced in patients with calcific lesions (94.1% vs. 83.9%, p=0.034) due to higher rates of periprocedural myocardial infarction (MI) (5% vs. 13.1%, p=0.067). During the median follow-up time of 14 months MACE rates (10.9% non-calcific vs. 12.9% calcific, plog-rank=0.546) were similar. Conclusions: Treating calcific lesions with BVS is feasible with high angiographic success rates, at the expense of longer procedure times, aggressive lesion preparation and increased rates of periprocedural MI.
AB - Aims: To compare the feasibility, procedural and clinical outcomes after implantation of bioresorbable vascular scaffolds (BVS) in patients with calcified lesions. Methods and results: We assessed the feasibility of BVS implantation and procedural outcomes in patients with and without calcific lesions. The primary outcome was angiographic and procedural success. Secondary outcomes included major adverse cardiovascular events (MACE). Of 163 patients, 62 (38%) had calcified lesions. Patients with calcific lesions had a higher prevalence of diabetes (35.5% vs. 22.8%, p=0.078) and chronic kidney disease (31.1% vs. 13.9%, p=0.008), and higher SYNTAX scores (18.9 ±9.7 vs. 15.1 ±9.0, p=0.017). Calcific lesions required longer procedures (126.4 ±39.8 vs. 106.9 ±37.1 min, p=0.015), more frequent use of dedicated devices and IVUS. Acute gain (1.83 ±0.6 vs. 1.86 ±0.6, p=0.732) and angiographic success were similar (98% non-calcific vs. 95.2% calcific, p=0.369), whereas procedural success was reduced in patients with calcific lesions (94.1% vs. 83.9%, p=0.034) due to higher rates of periprocedural myocardial infarction (MI) (5% vs. 13.1%, p=0.067). During the median follow-up time of 14 months MACE rates (10.9% non-calcific vs. 12.9% calcific, plog-rank=0.546) were similar. Conclusions: Treating calcific lesions with BVS is feasible with high angiographic success rates, at the expense of longer procedure times, aggressive lesion preparation and increased rates of periprocedural MI.
UR - http://www.scopus.com/inward/record.url?scp=84962137615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962137615&partnerID=8YFLogxK
U2 - 10.4244/EIJY15M03_11
DO - 10.4244/EIJY15M03_11
M3 - Article
C2 - 25868742
AN - SCOPUS:84962137615
SN - 1774-024X
VL - 11
SP - 1355
EP - 1362
JO - EuroIntervention
JF - EuroIntervention
IS - 12
ER -