Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical 'footprinting'

Michael Brenowitz, Mark R. Chance, Gauri Dhavan, Keiji Takamoto

Research output: Contribution to journalReview article

78 Scopus citations


For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.

Original languageEnglish (US)
Pages (from-to)648-653
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number5
Publication statusPublished - Oct 1 2002


ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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