For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.
|Original language||English (US)|
|Number of pages||6|
|Journal||Current Opinion in Structural Biology|
|State||Published - Oct 1 2002|
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology