Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical 'footprinting'

Michael Brenowitz; Mark R. Chance; Gauri Dhavan; Keiji Takamoto

doi:10.1016/S0959-440X(02)00366-4

Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical 'footprinting'

Michael Brenowitz, Mark R. Chance, Gauri Dhavan, Keiji Takamoto

Biochemistry

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.

Original language	English (US)
Pages (from-to)	648-653
Number of pages	6
Journal	Current Opinion in Structural Biology
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/S0959-440X(02)00366-4
State	Published - Oct 1 2002

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(02)00366-4

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abstract = "For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.",

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AB - For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.

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Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical 'footprinting'

Abstract

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