Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical 'footprinting'

Michael Brenowitz, Mark R. Chance, Gauri Dhavan, Keiji Takamoto

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.

Original languageEnglish (US)
Pages (from-to)648-653
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume12
Issue number5
DOIs
Publication statusPublished - Oct 1 2002

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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