Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical 'footprinting'

Michael D. Brenowitz, Mark R. Chance, Gauri Dhavan, Keiji Takamoto

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.

Original languageEnglish (US)
Pages (from-to)648-653
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2002

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Nucleic Acid Conformation
Hydroxyl Radical
Nucleic Acids
Ligands

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical 'footprinting'. / Brenowitz, Michael D.; Chance, Mark R.; Dhavan, Gauri; Takamoto, Keiji.

In: Current Opinion in Structural Biology, Vol. 12, No. 5, 01.10.2002, p. 648-653.

Research output: Contribution to journalArticle

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