Probing compulsive and impulsive behaviors, from animal models to endophenotypes: A narrative review

Naomi A. Fineberg, Marc N. Potenza, Samuel R. Chamberlain, Heather A. Berlin, Lara Menzies, Antoine Bechara, Barbara J. Sahakian, Trevor W. Robbins, Edward T. Bullmore, Eric Hollander

Research output: Contribution to journalArticle

357 Citations (Scopus)

Abstract

Failures in cortical control of fronto-striatal neural circuits may underpin impulsive and compulsive acts. In this narrative review, we explore these behaviors from the perspective of neural processes and consider how these behaviors and neural processes contribute to mental disorders such as obsessive-compulsive disorder (OCD), obsessive-compulsive personality disorder, and impulse-control disorders such as trichotillomania and pathological gambling. We present findings from a broad range of data, comprising translational and human endophenotypes research and clinical treatment trials, focussing on the parallel, functionally segregated, cortico-striatal neural projections, from orbitofrontal cortex (OFC) to medial striatum (caudate nucleus), proposed to drive compulsive activity, and from the anterior cingulate/ventromedial prefrontal cortex to the ventral striatum (nucleus accumbens shell), proposed to drive impulsive activity, and the interaction between them. We suggest that impulsivity and compulsivity each seem to be multidimensional. Impulsive or compulsive behaviors are mediated by overlapping as well as distinct neural substrates. Trichotillomania may stand apart as a disorder of motor-impulse control, whereas pathological gambling involves abnormal ventral reward circuitry that identifies it more closely with substance addiction. OCD shows motor impulsivity and compulsivity, probably mediated through disruption of OFC-caudate circuitry, as well as other frontal, cingulate, and parietal connections. Serotonin and dopamine interact across these circuits to modulate aspects of both impulsive and compulsive responding and as yet unidentified brain-based systems may also have important functions. Targeted application of neurocognitive tasks, receptor-specific neurochemical probes, and brain systems neuroimaging techniques have potential for future research in this field.

Original languageEnglish (US)
Pages (from-to)591-604
Number of pages14
JournalNeuropsychopharmacology
Volume35
Issue number3
DOIs
StatePublished - Feb 2010

Fingerprint

Compulsive Behavior
Endophenotypes
Impulsive Behavior
Obsessive-Compulsive Disorder
Compulsive Personality Disorder
Prefrontal Cortex
Trichotillomania
Disruptive, Impulse Control, and Conduct Disorders
Corpus Striatum
Gambling
Animal Models
Caudate Nucleus
Gyrus Cinguli
Nucleus Accumbens
Brain
Reward
Mental Disorders
Neuroimaging
Substance-Related Disorders
Dopamine

Keywords

  • Compulsive
  • Dopamine
  • Endophenotypes
  • Impulsive
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Fineberg, N. A., Potenza, M. N., Chamberlain, S. R., Berlin, H. A., Menzies, L., Bechara, A., ... Hollander, E. (2010). Probing compulsive and impulsive behaviors, from animal models to endophenotypes: A narrative review. Neuropsychopharmacology, 35(3), 591-604. https://doi.org/10.1038/npp.2009.185

Probing compulsive and impulsive behaviors, from animal models to endophenotypes : A narrative review. / Fineberg, Naomi A.; Potenza, Marc N.; Chamberlain, Samuel R.; Berlin, Heather A.; Menzies, Lara; Bechara, Antoine; Sahakian, Barbara J.; Robbins, Trevor W.; Bullmore, Edward T.; Hollander, Eric.

In: Neuropsychopharmacology, Vol. 35, No. 3, 02.2010, p. 591-604.

Research output: Contribution to journalArticle

Fineberg, NA, Potenza, MN, Chamberlain, SR, Berlin, HA, Menzies, L, Bechara, A, Sahakian, BJ, Robbins, TW, Bullmore, ET & Hollander, E 2010, 'Probing compulsive and impulsive behaviors, from animal models to endophenotypes: A narrative review', Neuropsychopharmacology, vol. 35, no. 3, pp. 591-604. https://doi.org/10.1038/npp.2009.185
Fineberg NA, Potenza MN, Chamberlain SR, Berlin HA, Menzies L, Bechara A et al. Probing compulsive and impulsive behaviors, from animal models to endophenotypes: A narrative review. Neuropsychopharmacology. 2010 Feb;35(3):591-604. https://doi.org/10.1038/npp.2009.185
Fineberg, Naomi A. ; Potenza, Marc N. ; Chamberlain, Samuel R. ; Berlin, Heather A. ; Menzies, Lara ; Bechara, Antoine ; Sahakian, Barbara J. ; Robbins, Trevor W. ; Bullmore, Edward T. ; Hollander, Eric. / Probing compulsive and impulsive behaviors, from animal models to endophenotypes : A narrative review. In: Neuropsychopharmacology. 2010 ; Vol. 35, No. 3. pp. 591-604.
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