Priming of memory but not effector CD8 T cells by a killed bacterial vaccine

G. Lauvau, S. Vijh, P. Kong, T. Horng, K. Kerksiek, N. Serbina, R. A. Tuma, E. G. Pamer

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241 Scopus citations

Abstract

Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity.

Original languageEnglish (US)
Pages (from-to)1735-1739
Number of pages5
JournalScience
Volume294
Issue number5547
DOIs
StatePublished - Nov 23 2001

ASJC Scopus subject areas

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    Lauvau, G., Vijh, S., Kong, P., Horng, T., Kerksiek, K., Serbina, N., Tuma, R. A., & Pamer, E. G. (2001). Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science, 294(5547), 1735-1739. https://doi.org/10.1126/science.1064571