TY - JOUR
T1 - Priming of memory but not effector CD8 T cells by a killed bacterial vaccine
AU - Lauvau, G.
AU - Vijh, S.
AU - Kong, P.
AU - Horng, T.
AU - Kerksiek, K.
AU - Serbina, N.
AU - Tuma, R. A.
AU - Pamer, E. G.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/11/23
Y1 - 2001/11/23
N2 - Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity.
AB - Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity.
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U2 - 10.1126/science.1064571
DO - 10.1126/science.1064571
M3 - Article
C2 - 11721060
AN - SCOPUS:0035941095
SN - 0036-8075
VL - 294
SP - 1735
EP - 1739
JO - Science
JF - Science
IS - 5547
ER -