Priming of memory but not effector CD8 T cells by a killed bacterial vaccine

Gregoire Lauvau, S. Vijh, P. Kong, T. Horng, K. Kerksiek, N. Serbina, R. A. Tuma, E. G. Pamer

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity.

Original languageEnglish (US)
Pages (from-to)1735-1739
Number of pages5
JournalScience
Volume294
Issue number5547
DOIs
StatePublished - Nov 23 2001
Externally publishedYes

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Bacterial Vaccines
Inactivated Vaccines
Listeria monocytogenes
T-Lymphocytes
Immunity
Hot Temperature
Immunization
Listeriosis
Infection
Cellular Immunity
Vaccination

ASJC Scopus subject areas

  • General

Cite this

Lauvau, G., Vijh, S., Kong, P., Horng, T., Kerksiek, K., Serbina, N., ... Pamer, E. G. (2001). Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science, 294(5547), 1735-1739. https://doi.org/10.1126/science.1064571

Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. / Lauvau, Gregoire; Vijh, S.; Kong, P.; Horng, T.; Kerksiek, K.; Serbina, N.; Tuma, R. A.; Pamer, E. G.

In: Science, Vol. 294, No. 5547, 23.11.2001, p. 1735-1739.

Research output: Contribution to journalArticle

Lauvau, G, Vijh, S, Kong, P, Horng, T, Kerksiek, K, Serbina, N, Tuma, RA & Pamer, EG 2001, 'Priming of memory but not effector CD8 T cells by a killed bacterial vaccine', Science, vol. 294, no. 5547, pp. 1735-1739. https://doi.org/10.1126/science.1064571
Lauvau G, Vijh S, Kong P, Horng T, Kerksiek K, Serbina N et al. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science. 2001 Nov 23;294(5547):1735-1739. https://doi.org/10.1126/science.1064571
Lauvau, Gregoire ; Vijh, S. ; Kong, P. ; Horng, T. ; Kerksiek, K. ; Serbina, N. ; Tuma, R. A. ; Pamer, E. G. / Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. In: Science. 2001 ; Vol. 294, No. 5547. pp. 1735-1739.
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