TY - JOUR
T1 - Primary intestinal posttransplant T-cell lymphoma
AU - Michael, J.
AU - Greenstein, S.
AU - Schechner, R.
AU - Tellis, V.
AU - Vasovic, L. V.
AU - Ratech, H.
AU - Glicklich, Daniel
PY - 2003/6/27
Y1 - 2003/6/27
N2 - There have been only five reported cases of primary posttransplant T-cell lymphoma. We report the first case associated with the use of sirolimus (Rapamycin, Wyeth-Ayerst, Philadelphia, PA). The patient, receiving prednisone, cyclosporine, and sirolimus treatment, developed ascites, diarrhea, and weight loss 7 months after his second renal transplant. Tissue obtained at laparotomy established the diagnosis of primary T-cell lymphoma. Latent membrane protein-1 for Epstein-Barr virus was negative, but in-site hybridization test for Epstein-Barr-encoded RNA was positive. Despite aggressive chemotherapy, the patient died 8 months posttransplant. This is the sixth reported case of primary intestinal posttransplant T-cell lymphoma, but it is the first case associated with the use of sirolimus. The incidence of posttransplant lymphoproliferative disease in patients receiving sirolimus should be studied.
AB - There have been only five reported cases of primary posttransplant T-cell lymphoma. We report the first case associated with the use of sirolimus (Rapamycin, Wyeth-Ayerst, Philadelphia, PA). The patient, receiving prednisone, cyclosporine, and sirolimus treatment, developed ascites, diarrhea, and weight loss 7 months after his second renal transplant. Tissue obtained at laparotomy established the diagnosis of primary T-cell lymphoma. Latent membrane protein-1 for Epstein-Barr virus was negative, but in-site hybridization test for Epstein-Barr-encoded RNA was positive. Despite aggressive chemotherapy, the patient died 8 months posttransplant. This is the sixth reported case of primary intestinal posttransplant T-cell lymphoma, but it is the first case associated with the use of sirolimus. The incidence of posttransplant lymphoproliferative disease in patients receiving sirolimus should be studied.
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U2 - 10.1097/01.TP.0000060253.54333.F3
DO - 10.1097/01.TP.0000060253.54333.F3
M3 - Article
C2 - 12829924
AN - SCOPUS:0038451501
SN - 0041-1337
VL - 75
SP - 2131
EP - 2132
JO - Transplantation
JF - Transplantation
IS - 12
ER -