Primary immunodeficiencies of the B lymphocyte.

Ana Moise, Filofteia Daniela Nedelcu, Maria Adela Toader, Steluta Mihaela Sora, Anca Tica, Denisa E. Ferastraoaru, Ileana Constantinescu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The immune response consists of two main components: humoral immunity represented by B lymphocytes and cellular immunity maintained by the T lymphocytes. Immunoglobulins, produced by B-lymphocytes, are the main mediators of humoral immunity, and deficiencies at this level affect the body's response to infection. Plasmocytes produce nine antibody izotypes: immunoglobulins G (IgG1, IgG2, IgG3, IgG4), immunoglobulins M (IgM), immunoglobulins A (IgA1, IgA2), immunoglobulins D (IGD) and immunoglobulins E (IgE). Primary hypogammaglobulinemias are characterized by the occurrence of recurrent infections and, paradoxically, by the occurrence of autoimmune diseases. Characteristic for these diseases is that symptoms occur at 7-9 months after birth, when transplacental antibody titers transmitted from the mother decrease, and the infant's body is unable to synthesize them to normal levels. Primary hypogammaglobulinemias are transmitted genetically, but mutations at the molecular level are still not fully understood. The most common are: Bruton agammaglobulinemia, transient newborn hypogammaglobulinemia, selective immunoglobulin deficiency and variable common immunodeficiency. Treatment consists of monthly antibiotics and immunoglobulins, depending on antibody titers (except for IgA deficiency).

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalJournal of medicine and life
Volume3
Issue number1
StatePublished - Jan 2010
Externally publishedYes

Fingerprint

B-Lymphocytes
Immunoglobulin G
Immunoglobulin A
Humoral Immunity
Antibodies
Immunoglobulins
IgA Deficiency
Common Variable Immunodeficiency
Immunoglobulin D
Agammaglobulinemia
Lymphokines
Infection
Cellular Immunity
Immunoglobulin E
Autoimmune Diseases
Immunoglobulin M
Mothers
Parturition
Newborn Infant
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Moise, A., Nedelcu, F. D., Toader, M. A., Sora, S. M., Tica, A., Ferastraoaru, D. E., & Constantinescu, I. (2010). Primary immunodeficiencies of the B lymphocyte. Journal of medicine and life, 3(1), 60-63.

Primary immunodeficiencies of the B lymphocyte. / Moise, Ana; Nedelcu, Filofteia Daniela; Toader, Maria Adela; Sora, Steluta Mihaela; Tica, Anca; Ferastraoaru, Denisa E.; Constantinescu, Ileana.

In: Journal of medicine and life, Vol. 3, No. 1, 01.2010, p. 60-63.

Research output: Contribution to journalArticle

Moise, A, Nedelcu, FD, Toader, MA, Sora, SM, Tica, A, Ferastraoaru, DE & Constantinescu, I 2010, 'Primary immunodeficiencies of the B lymphocyte.', Journal of medicine and life, vol. 3, no. 1, pp. 60-63.
Moise A, Nedelcu FD, Toader MA, Sora SM, Tica A, Ferastraoaru DE et al. Primary immunodeficiencies of the B lymphocyte. Journal of medicine and life. 2010 Jan;3(1):60-63.
Moise, Ana ; Nedelcu, Filofteia Daniela ; Toader, Maria Adela ; Sora, Steluta Mihaela ; Tica, Anca ; Ferastraoaru, Denisa E. ; Constantinescu, Ileana. / Primary immunodeficiencies of the B lymphocyte. In: Journal of medicine and life. 2010 ; Vol. 3, No. 1. pp. 60-63.
@article{4d251d952829420e940f372ac462c113,
title = "Primary immunodeficiencies of the B lymphocyte.",
abstract = "The immune response consists of two main components: humoral immunity represented by B lymphocytes and cellular immunity maintained by the T lymphocytes. Immunoglobulins, produced by B-lymphocytes, are the main mediators of humoral immunity, and deficiencies at this level affect the body's response to infection. Plasmocytes produce nine antibody izotypes: immunoglobulins G (IgG1, IgG2, IgG3, IgG4), immunoglobulins M (IgM), immunoglobulins A (IgA1, IgA2), immunoglobulins D (IGD) and immunoglobulins E (IgE). Primary hypogammaglobulinemias are characterized by the occurrence of recurrent infections and, paradoxically, by the occurrence of autoimmune diseases. Characteristic for these diseases is that symptoms occur at 7-9 months after birth, when transplacental antibody titers transmitted from the mother decrease, and the infant's body is unable to synthesize them to normal levels. Primary hypogammaglobulinemias are transmitted genetically, but mutations at the molecular level are still not fully understood. The most common are: Bruton agammaglobulinemia, transient newborn hypogammaglobulinemia, selective immunoglobulin deficiency and variable common immunodeficiency. Treatment consists of monthly antibiotics and immunoglobulins, depending on antibody titers (except for IgA deficiency).",
author = "Ana Moise and Nedelcu, {Filofteia Daniela} and Toader, {Maria Adela} and Sora, {Steluta Mihaela} and Anca Tica and Ferastraoaru, {Denisa E.} and Ileana Constantinescu",
year = "2010",
month = "1",
language = "English (US)",
volume = "3",
pages = "60--63",
journal = "Journal of medicine and life",
issn = "1844-122X",
publisher = "Carol Davila University Press",
number = "1",

}

TY - JOUR

T1 - Primary immunodeficiencies of the B lymphocyte.

AU - Moise, Ana

AU - Nedelcu, Filofteia Daniela

AU - Toader, Maria Adela

AU - Sora, Steluta Mihaela

AU - Tica, Anca

AU - Ferastraoaru, Denisa E.

AU - Constantinescu, Ileana

PY - 2010/1

Y1 - 2010/1

N2 - The immune response consists of two main components: humoral immunity represented by B lymphocytes and cellular immunity maintained by the T lymphocytes. Immunoglobulins, produced by B-lymphocytes, are the main mediators of humoral immunity, and deficiencies at this level affect the body's response to infection. Plasmocytes produce nine antibody izotypes: immunoglobulins G (IgG1, IgG2, IgG3, IgG4), immunoglobulins M (IgM), immunoglobulins A (IgA1, IgA2), immunoglobulins D (IGD) and immunoglobulins E (IgE). Primary hypogammaglobulinemias are characterized by the occurrence of recurrent infections and, paradoxically, by the occurrence of autoimmune diseases. Characteristic for these diseases is that symptoms occur at 7-9 months after birth, when transplacental antibody titers transmitted from the mother decrease, and the infant's body is unable to synthesize them to normal levels. Primary hypogammaglobulinemias are transmitted genetically, but mutations at the molecular level are still not fully understood. The most common are: Bruton agammaglobulinemia, transient newborn hypogammaglobulinemia, selective immunoglobulin deficiency and variable common immunodeficiency. Treatment consists of monthly antibiotics and immunoglobulins, depending on antibody titers (except for IgA deficiency).

AB - The immune response consists of two main components: humoral immunity represented by B lymphocytes and cellular immunity maintained by the T lymphocytes. Immunoglobulins, produced by B-lymphocytes, are the main mediators of humoral immunity, and deficiencies at this level affect the body's response to infection. Plasmocytes produce nine antibody izotypes: immunoglobulins G (IgG1, IgG2, IgG3, IgG4), immunoglobulins M (IgM), immunoglobulins A (IgA1, IgA2), immunoglobulins D (IGD) and immunoglobulins E (IgE). Primary hypogammaglobulinemias are characterized by the occurrence of recurrent infections and, paradoxically, by the occurrence of autoimmune diseases. Characteristic for these diseases is that symptoms occur at 7-9 months after birth, when transplacental antibody titers transmitted from the mother decrease, and the infant's body is unable to synthesize them to normal levels. Primary hypogammaglobulinemias are transmitted genetically, but mutations at the molecular level are still not fully understood. The most common are: Bruton agammaglobulinemia, transient newborn hypogammaglobulinemia, selective immunoglobulin deficiency and variable common immunodeficiency. Treatment consists of monthly antibiotics and immunoglobulins, depending on antibody titers (except for IgA deficiency).

UR - http://www.scopus.com/inward/record.url?scp=77950515224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950515224&partnerID=8YFLogxK

M3 - Article

C2 - 20302197

AN - SCOPUS:77950515224

VL - 3

SP - 60

EP - 63

JO - Journal of medicine and life

JF - Journal of medicine and life

SN - 1844-122X

IS - 1

ER -