Primary gastric T-Cell lymphoma with cutaneous involvement: A case report and review of the literature

Reza Naghavi, Daisy Saw, Terence Brady, Mitchell Kaplan, Clement Tagoe

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Primary gastric T-cell lymphomas are extremely rare. We report a Ki-1 negative primary gastric T-cell lymphoma of the anaplastic large cell type associated with extensive involvement of the skin, gastrointestinal tract, and other organ involvement in a patient not known to be immunocompromized. Biopsy of the stomach and distal esophagus showed infiltration of gastric mucosa and the squamous epithelium by nests of large atypical cells with vacuolated or clear cytoplasm, consistent with large cell lymphoma. Immunohisto-chemical staining of these specimens revealed neoplastic cells bearing LCA(CD45) and T-cell markers (UCHL1/CD45R0 and CD3). This represents the only case so far with synchronous presentation of gastric, esophageal, and cutaneous involvement without evidence of regional lymph node involvement. There was no association with HTLV-1 or HIV infection. The patient had a fulminant course and a poor response to chemotherapy.

Original languageEnglish (US)
Pages (from-to)312-316
Number of pages5
JournalJournal of clinical gastroenterology
Volume21
Issue number4
DOIs
StatePublished - Dec 1995
Externally publishedYes

Keywords

  • Cutaneous
  • Primary gastric
  • T-Cell lymphoma

ASJC Scopus subject areas

  • Gastroenterology

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