Primary gastric T-Cell lymphoma with cutaneous involvement

A case report and review of the literature

Reza Naghavi, Daisy Saw, Terence Brady, Mitchell Kaplan, Clement E. Tagoe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Primary gastric T-cell lymphomas are extremely rare. We report a Ki-1 negative primary gastric T-cell lymphoma of the anaplastic large cell type associated with extensive involvement of the skin, gastrointestinal tract, and other organ involvement in a patient not known to be immunocompromized. Biopsy of the stomach and distal esophagus showed infiltration of gastric mucosa and the squamous epithelium by nests of large atypical cells with vacuolated or clear cytoplasm, consistent with large cell lymphoma. Immunohisto-chemical staining of these specimens revealed neoplastic cells bearing LCA(CD45) and T-cell markers (UCHL1/CD45R0 and CD3). This represents the only case so far with synchronous presentation of gastric, esophageal, and cutaneous involvement without evidence of regional lymph node involvement. There was no association with HTLV-1 or HIV infection. The patient had a fulminant course and a poor response to chemotherapy.

Original languageEnglish (US)
Pages (from-to)312-316
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume21
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Cutaneous T-Cell Lymphoma
Stomach
T-Cell Lymphoma
Deltaretrovirus Infections
Skin
Human T-lymphotropic virus 1
Gastric Mucosa
Esophagus
HIV Infections
Gastrointestinal Tract
Lymphoma
Cytoplasm
Epithelium
Lymph Nodes
Staining and Labeling
T-Lymphocytes
Biopsy
Drug Therapy

Keywords

  • Cutaneous
  • Primary gastric
  • T-Cell lymphoma

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Primary gastric T-Cell lymphoma with cutaneous involvement : A case report and review of the literature. / Naghavi, Reza; Saw, Daisy; Brady, Terence; Kaplan, Mitchell; Tagoe, Clement E.

In: Journal of Clinical Gastroenterology, Vol. 21, No. 4, 1995, p. 312-316.

Research output: Contribution to journalArticle

Naghavi, Reza ; Saw, Daisy ; Brady, Terence ; Kaplan, Mitchell ; Tagoe, Clement E. / Primary gastric T-Cell lymphoma with cutaneous involvement : A case report and review of the literature. In: Journal of Clinical Gastroenterology. 1995 ; Vol. 21, No. 4. pp. 312-316.
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