Primary cutaneous smoldering adult t-cell leukemia/ lymphoma

Julia Gittler, Kathryn Martires, Vitaly Terushkin, Nooshin Brinster, David Ramsay

Research output: Contribution to journalArticle

Abstract

HTLV-1 is a virus that is endemic in southwestern Japan and the Caribbean and has been implicated in the development of ATLL. ATLL, which is an uncommon malignant condition of peripheral T-lymphocytes, is characterized by four clinical subtypes, which include acute, lymphomatous, chronic, and smoldering types, that are based on LDH levels, calcium levels, and extent of organ involvement. We present a 52-year- old woman with pruritic patches with scale on the buttocks and with tender, hyperpigmented macules and papules of two-years duration. Histopathologic examination was suggestive of mycosis fungoides, laboratory results showed HTLV-I and II, and the patient was diagnosed with primary cutaneous ATLL. We review the literature on HTLV-1 and ATLL and specifically the prognosis of cutaneous ATLL. The literature suggests that a diagnosis of ATLL should be considered among patients of Caribbean origin or other endemic areas with skin lesions that suggest a cutaneous T-cell lymphoma, with clinicopathologic features of mycosis fungoides. Differentiation between ATLL and cutaneous T-cell lymphoma is imperative as they have different prognoses and treatment approaches.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalDermatology Online Journal
Volume22
Issue number12
StatePublished - Jan 1 2016
Externally publishedYes

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Adult T Cell Leukemia Lymphoma
Lymphoma
Leukemia
Skin
Human T-lymphotropic virus 1
Cutaneous T-Cell Lymphoma
Mycosis Fungoides
Human T-lymphotropic virus 2
Buttocks
Japan
Viruses
Calcium
T-Lymphocytes

ASJC Scopus subject areas

  • Dermatology

Cite this

Gittler, J., Martires, K., Terushkin, V., Brinster, N., & Ramsay, D. (2016). Primary cutaneous smoldering adult t-cell leukemia/ lymphoma. Dermatology Online Journal, 22(12), 23-26.

Primary cutaneous smoldering adult t-cell leukemia/ lymphoma. / Gittler, Julia; Martires, Kathryn; Terushkin, Vitaly; Brinster, Nooshin; Ramsay, David.

In: Dermatology Online Journal, Vol. 22, No. 12, 01.01.2016, p. 23-26.

Research output: Contribution to journalArticle

Gittler, J, Martires, K, Terushkin, V, Brinster, N & Ramsay, D 2016, 'Primary cutaneous smoldering adult t-cell leukemia/ lymphoma', Dermatology Online Journal, vol. 22, no. 12, pp. 23-26.
Gittler J, Martires K, Terushkin V, Brinster N, Ramsay D. Primary cutaneous smoldering adult t-cell leukemia/ lymphoma. Dermatology Online Journal. 2016 Jan 1;22(12):23-26.
Gittler, Julia ; Martires, Kathryn ; Terushkin, Vitaly ; Brinster, Nooshin ; Ramsay, David. / Primary cutaneous smoldering adult t-cell leukemia/ lymphoma. In: Dermatology Online Journal. 2016 ; Vol. 22, No. 12. pp. 23-26.
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