Abstract
The current mainstay of immunotherapy in clinical transplantation is T lymphocyte directed. However, it has long been appreciated that the emergence of an alloimmune response mounted by the B lymphocyte compartment and detectable as donor-specific antibodies is a critical challenge to long-term graft survival. Thus, achieving robust transplantation tolerance will require induction of tolerance in both the T- and B-cell compartments. Here we propose that the natural developmental propensity of the B-lymphocyte compartment acquisition of tolerance to self-antigens can be recapitulated to achieve humoral transplantation tolerance. It is our contention B-lymphocyte directed induction immunotherapy would be an important component of emerging strategies for induction of Transplantation tolerance.
Original language | English (US) |
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Pages (from-to) | 109-114 |
Number of pages | 6 |
Journal | Seminars in Immunology |
Volume | 24 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2012 |
Externally published | Yes |
Keywords
- B lymphocytes
- BLyS
- Humoral tolerance
- Transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology