Primary B cell repertoire remodeling to achieve humoral transplantation tolerance

Ronald F. Parsons, Robert R. Redfield, Eduardo Rodriguez, Moiz M. Mustafa, Kumar Vivek, Michael Murayama, Ali Naji, Hooman Noorchashm

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

The current mainstay of immunotherapy in clinical transplantation is T lymphocyte directed. However, it has long been appreciated that the emergence of an alloimmune response mounted by the B lymphocyte compartment and detectable as donor-specific antibodies is a critical challenge to long-term graft survival. Thus, achieving robust transplantation tolerance will require induction of tolerance in both the T- and B-cell compartments. Here we propose that the natural developmental propensity of the B-lymphocyte compartment acquisition of tolerance to self-antigens can be recapitulated to achieve humoral transplantation tolerance. It is our contention B-lymphocyte directed induction immunotherapy would be an important component of emerging strategies for induction of Transplantation tolerance.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalSeminars in Immunology
Volume24
Issue number2
DOIs
Publication statusPublished - Apr 1 2012
Externally publishedYes

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Keywords

  • B lymphocytes
  • BLyS
  • Humoral tolerance
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Parsons, R. F., Redfield, R. R., Rodriguez, E., Mustafa, M. M., Vivek, K., Murayama, M., ... Noorchashm, H. (2012). Primary B cell repertoire remodeling to achieve humoral transplantation tolerance. Seminars in Immunology, 24(2), 109-114. https://doi.org/10.1016/j.smim.2011.08.016