Primary and metastatic high-grade carcinomas of the salivary glands

A cytologic-histologic correlation study of twenty cases

M. W. Stanley, R. H. Bardales, C. E. Farmer, H. F. Frierson, Mark J. Suhrland, C. N. Powers, S. D. Rollins

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We reviewed the clinical and fine-needle aspiration (FNA) findings in 20 patients with poorly differentiated carcinomas presenting initially as parotid or as submandibular masses. There were 11 primary tumors and nine metastatic malignancies in 14 males and six females ranging in age from 39 to 89 yr (median = 66). The tumor types included three primary carcinomas with oncocytic features, three additional cases of high-grade parotid carcinoma, one case of primary neuroendocrine carcinoma, two examples of malignant mixed tumor, one high-grade mucoepidermoid carcinoma, and a single example of malignant lymphoepithelial lesion. Six patients with metastatic carcinoma had previous diagnoses of malignancy. In the three remaining individuals, primary carcinomas of the lung (two cases), and an unknown primary site presented initially as parotid masses. Five examples of metastatic squamous cell carcinoma, one metastatic basal cell carcinoma, and two metastatic renal cell carcinomas were identified. One parotid lymphoepithelioma was interpreted cytologically as anatypical lymphoproliferative process suggestive of Hodgkin's disease. Nineteen cases (95%) were correctly classified as carcinoma at the time of FNA. High-grade carcinomas aspirated from the parotid may be primary, but are frequently metastatic to either the gland, or to an intraparotid lymph node. Our experience indicates that some metastatic carcinomas present at this site, without a previous history of malignancy. Distinguishing primary from metastatic lesions has important therapeutic implications.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalDiagnostic Cytopathology
Volume13
Issue number1
DOIs
StatePublished - 1995

Fingerprint

Salivary Glands
Carcinoma
Neoplasms
Fine Needle Biopsy
Malignant Mixed Tumor
Mucoepidermoid Carcinoma
Neuroendocrine Carcinoma
Basal Cell Carcinoma
Hodgkin Disease
Renal Cell Carcinoma
Squamous Cell Carcinoma
Lymph Nodes
Lung

Keywords

  • Carcinoma
  • Cytology
  • Fine-needle aspiration
  • Malignancy
  • Metastases
  • Parotid
  • Salivary gland

ASJC Scopus subject areas

  • Anatomy

Cite this

Primary and metastatic high-grade carcinomas of the salivary glands : A cytologic-histologic correlation study of twenty cases. / Stanley, M. W.; Bardales, R. H.; Farmer, C. E.; Frierson, H. F.; Suhrland, Mark J.; Powers, C. N.; Rollins, S. D.

In: Diagnostic Cytopathology, Vol. 13, No. 1, 1995, p. 37-43.

Research output: Contribution to journalArticle

Stanley, M. W. ; Bardales, R. H. ; Farmer, C. E. ; Frierson, H. F. ; Suhrland, Mark J. ; Powers, C. N. ; Rollins, S. D. / Primary and metastatic high-grade carcinomas of the salivary glands : A cytologic-histologic correlation study of twenty cases. In: Diagnostic Cytopathology. 1995 ; Vol. 13, No. 1. pp. 37-43.
@article{e6b9645b8b5947a8b4223469c8d704c4,
title = "Primary and metastatic high-grade carcinomas of the salivary glands: A cytologic-histologic correlation study of twenty cases",
abstract = "We reviewed the clinical and fine-needle aspiration (FNA) findings in 20 patients with poorly differentiated carcinomas presenting initially as parotid or as submandibular masses. There were 11 primary tumors and nine metastatic malignancies in 14 males and six females ranging in age from 39 to 89 yr (median = 66). The tumor types included three primary carcinomas with oncocytic features, three additional cases of high-grade parotid carcinoma, one case of primary neuroendocrine carcinoma, two examples of malignant mixed tumor, one high-grade mucoepidermoid carcinoma, and a single example of malignant lymphoepithelial lesion. Six patients with metastatic carcinoma had previous diagnoses of malignancy. In the three remaining individuals, primary carcinomas of the lung (two cases), and an unknown primary site presented initially as parotid masses. Five examples of metastatic squamous cell carcinoma, one metastatic basal cell carcinoma, and two metastatic renal cell carcinomas were identified. One parotid lymphoepithelioma was interpreted cytologically as anatypical lymphoproliferative process suggestive of Hodgkin's disease. Nineteen cases (95{\%}) were correctly classified as carcinoma at the time of FNA. High-grade carcinomas aspirated from the parotid may be primary, but are frequently metastatic to either the gland, or to an intraparotid lymph node. Our experience indicates that some metastatic carcinomas present at this site, without a previous history of malignancy. Distinguishing primary from metastatic lesions has important therapeutic implications.",
keywords = "Carcinoma, Cytology, Fine-needle aspiration, Malignancy, Metastases, Parotid, Salivary gland",
author = "Stanley, {M. W.} and Bardales, {R. H.} and Farmer, {C. E.} and Frierson, {H. F.} and Suhrland, {Mark J.} and Powers, {C. N.} and Rollins, {S. D.}",
year = "1995",
doi = "10.1002/dc.2840130109",
language = "English (US)",
volume = "13",
pages = "37--43",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Primary and metastatic high-grade carcinomas of the salivary glands

T2 - A cytologic-histologic correlation study of twenty cases

AU - Stanley, M. W.

AU - Bardales, R. H.

AU - Farmer, C. E.

AU - Frierson, H. F.

AU - Suhrland, Mark J.

AU - Powers, C. N.

AU - Rollins, S. D.

PY - 1995

Y1 - 1995

N2 - We reviewed the clinical and fine-needle aspiration (FNA) findings in 20 patients with poorly differentiated carcinomas presenting initially as parotid or as submandibular masses. There were 11 primary tumors and nine metastatic malignancies in 14 males and six females ranging in age from 39 to 89 yr (median = 66). The tumor types included three primary carcinomas with oncocytic features, three additional cases of high-grade parotid carcinoma, one case of primary neuroendocrine carcinoma, two examples of malignant mixed tumor, one high-grade mucoepidermoid carcinoma, and a single example of malignant lymphoepithelial lesion. Six patients with metastatic carcinoma had previous diagnoses of malignancy. In the three remaining individuals, primary carcinomas of the lung (two cases), and an unknown primary site presented initially as parotid masses. Five examples of metastatic squamous cell carcinoma, one metastatic basal cell carcinoma, and two metastatic renal cell carcinomas were identified. One parotid lymphoepithelioma was interpreted cytologically as anatypical lymphoproliferative process suggestive of Hodgkin's disease. Nineteen cases (95%) were correctly classified as carcinoma at the time of FNA. High-grade carcinomas aspirated from the parotid may be primary, but are frequently metastatic to either the gland, or to an intraparotid lymph node. Our experience indicates that some metastatic carcinomas present at this site, without a previous history of malignancy. Distinguishing primary from metastatic lesions has important therapeutic implications.

AB - We reviewed the clinical and fine-needle aspiration (FNA) findings in 20 patients with poorly differentiated carcinomas presenting initially as parotid or as submandibular masses. There were 11 primary tumors and nine metastatic malignancies in 14 males and six females ranging in age from 39 to 89 yr (median = 66). The tumor types included three primary carcinomas with oncocytic features, three additional cases of high-grade parotid carcinoma, one case of primary neuroendocrine carcinoma, two examples of malignant mixed tumor, one high-grade mucoepidermoid carcinoma, and a single example of malignant lymphoepithelial lesion. Six patients with metastatic carcinoma had previous diagnoses of malignancy. In the three remaining individuals, primary carcinomas of the lung (two cases), and an unknown primary site presented initially as parotid masses. Five examples of metastatic squamous cell carcinoma, one metastatic basal cell carcinoma, and two metastatic renal cell carcinomas were identified. One parotid lymphoepithelioma was interpreted cytologically as anatypical lymphoproliferative process suggestive of Hodgkin's disease. Nineteen cases (95%) were correctly classified as carcinoma at the time of FNA. High-grade carcinomas aspirated from the parotid may be primary, but are frequently metastatic to either the gland, or to an intraparotid lymph node. Our experience indicates that some metastatic carcinomas present at this site, without a previous history of malignancy. Distinguishing primary from metastatic lesions has important therapeutic implications.

KW - Carcinoma

KW - Cytology

KW - Fine-needle aspiration

KW - Malignancy

KW - Metastases

KW - Parotid

KW - Salivary gland

UR - http://www.scopus.com/inward/record.url?scp=0029042873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029042873&partnerID=8YFLogxK

U2 - 10.1002/dc.2840130109

DO - 10.1002/dc.2840130109

M3 - Article

VL - 13

SP - 37

EP - 43

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

IS - 1

ER -