Prickle and strabismus form a functional complex to generate a correct axis during planar cell polarity signaling

Andreas Jenny, Rachel S. Darken, Paul A. Wilson, Marek Mlodzik

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Frizzled (Fz) signaling regulates the establishment of planar cell polarity (PCP). The PCP genes prickle (pk) and strabismus (stbm) are thought to antagonize Fz signaling. We show that they act in the same cell, R4, adjacent to that in which the Fz/PCP pathway is required in the Drosophila eye. We demonstrate that Stbm and Pk interact physically and that Stbm recruits Pk to the cell membrane. Through this interaction, Pk affects Stbm membrane localization and can cause clustering of Stbm. Pk is also known to interact with Dsh and is thought to antagonize Dsh by affecting its membrane localization. Thus our data suggest that the Stbm/Pk complex modulates Fz/Dsh activity, resulting in a symmetry-breaking step during polarity signaling.

Original languageEnglish (US)
Pages (from-to)4409-4420
Number of pages12
JournalEMBO Journal
Volume22
Issue number17
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Fingerprint

Cell Polarity
Strabismus
Membranes
Cell membranes
Drosophila
Cluster Analysis
Genes
Cell Membrane

Keywords

  • Convergent extension
  • Frizzled
  • Planar cell polarity
  • Prickle
  • Strabismus

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Prickle and strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. / Jenny, Andreas; Darken, Rachel S.; Wilson, Paul A.; Mlodzik, Marek.

In: EMBO Journal, Vol. 22, No. 17, 01.09.2003, p. 4409-4420.

Research output: Contribution to journalArticle

Jenny, Andreas ; Darken, Rachel S. ; Wilson, Paul A. ; Mlodzik, Marek. / Prickle and strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. In: EMBO Journal. 2003 ; Vol. 22, No. 17. pp. 4409-4420.
@article{7ac91cdf42e945c0a1a0d71631cb0030,
title = "Prickle and strabismus form a functional complex to generate a correct axis during planar cell polarity signaling",
abstract = "Frizzled (Fz) signaling regulates the establishment of planar cell polarity (PCP). The PCP genes prickle (pk) and strabismus (stbm) are thought to antagonize Fz signaling. We show that they act in the same cell, R4, adjacent to that in which the Fz/PCP pathway is required in the Drosophila eye. We demonstrate that Stbm and Pk interact physically and that Stbm recruits Pk to the cell membrane. Through this interaction, Pk affects Stbm membrane localization and can cause clustering of Stbm. Pk is also known to interact with Dsh and is thought to antagonize Dsh by affecting its membrane localization. Thus our data suggest that the Stbm/Pk complex modulates Fz/Dsh activity, resulting in a symmetry-breaking step during polarity signaling.",
keywords = "Convergent extension, Frizzled, Planar cell polarity, Prickle, Strabismus",
author = "Andreas Jenny and Darken, {Rachel S.} and Wilson, {Paul A.} and Marek Mlodzik",
year = "2003",
month = "9",
day = "1",
doi = "10.1093/emboj/cdg424",
language = "English (US)",
volume = "22",
pages = "4409--4420",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Nature Publishing Group",
number = "17",

}

TY - JOUR

T1 - Prickle and strabismus form a functional complex to generate a correct axis during planar cell polarity signaling

AU - Jenny, Andreas

AU - Darken, Rachel S.

AU - Wilson, Paul A.

AU - Mlodzik, Marek

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Frizzled (Fz) signaling regulates the establishment of planar cell polarity (PCP). The PCP genes prickle (pk) and strabismus (stbm) are thought to antagonize Fz signaling. We show that they act in the same cell, R4, adjacent to that in which the Fz/PCP pathway is required in the Drosophila eye. We demonstrate that Stbm and Pk interact physically and that Stbm recruits Pk to the cell membrane. Through this interaction, Pk affects Stbm membrane localization and can cause clustering of Stbm. Pk is also known to interact with Dsh and is thought to antagonize Dsh by affecting its membrane localization. Thus our data suggest that the Stbm/Pk complex modulates Fz/Dsh activity, resulting in a symmetry-breaking step during polarity signaling.

AB - Frizzled (Fz) signaling regulates the establishment of planar cell polarity (PCP). The PCP genes prickle (pk) and strabismus (stbm) are thought to antagonize Fz signaling. We show that they act in the same cell, R4, adjacent to that in which the Fz/PCP pathway is required in the Drosophila eye. We demonstrate that Stbm and Pk interact physically and that Stbm recruits Pk to the cell membrane. Through this interaction, Pk affects Stbm membrane localization and can cause clustering of Stbm. Pk is also known to interact with Dsh and is thought to antagonize Dsh by affecting its membrane localization. Thus our data suggest that the Stbm/Pk complex modulates Fz/Dsh activity, resulting in a symmetry-breaking step during polarity signaling.

KW - Convergent extension

KW - Frizzled

KW - Planar cell polarity

KW - Prickle

KW - Strabismus

UR - http://www.scopus.com/inward/record.url?scp=0041736696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041736696&partnerID=8YFLogxK

U2 - 10.1093/emboj/cdg424

DO - 10.1093/emboj/cdg424

M3 - Article

C2 - 12941693

AN - SCOPUS:0041736696

VL - 22

SP - 4409

EP - 4420

JO - EMBO Journal

JF - EMBO Journal

SN - 0261-4189

IS - 17

ER -