Preventive effect of S-allyl cysteine sulfoxide (alliin) on lysosomal hydrolases and membrane-bound ATPases in isoproterenol-induced myocardial infarction in wistar rats

T. Sangeetha, S. Darlin Quine

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In this study, S-allyl cysteine sulfoxide (SACS) was used to evaluate its preventive effect in isoproterenol (ISO)-induced myocardial ischemia in male Wistar rats. Rats were pretreated with SACS (40 and 80 mg kg-1) orally for 5 weeks. After the treatment period, ISO (150 mg kg-1) was administered subcutaneously to rats at an interval of 24 h for 2 days. The activities of β-D-N-acetyl-glucosaminidase, β-galactosidase, β-glucosidase, and acid phosphatase increased in serum and heart in ISO-induced rats. In addition, these rats showed a significant (p < 0.05) increase in the activities of β-glucuronidase and cathepsin-D in serum and heart and a significant (p < 0.05) decrease in their activities in lysosomal fraction of the heart. The activity of Na+K+-ATPase declined, while those of Ca2+- and Mg2+-ATPases significantly (p < 0.05) elevated in the heart of ISO-induced rats. Pretreatment with SACS (40 and 80 mg kg-1) showed a significant (p < 0.05) effect in all the biochemical parameters studied. The effect at a dose of 80 mg kg-1 body weight was more effective than that at 40 mg kg-1 body weight and brought back all the biochemical parameters to near normal levels. Hereby, our study shows the membrane-stabilizing as well as antioxidant effects of SACS in ISO-induced rats.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalJournal of Biochemical and Molecular Toxicology
Volume21
Issue number3
DOIs
StatePublished - Jul 24 2007

Keywords

  • Alliin
  • Isoproterenol
  • Lysosomal hydrolases
  • Myocardial infarction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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