Prevention of post-stroke generalized anxiety disorder, Using escitalopram or problem- solving therapy

Katsunaka Mikami, Ricardo E. Jorge, David J. Moser, Stephan Arndt, Mijin Jang, Ana Solodkin, Steven L. Small, Pasquale Fonzetti, Mark T. Hegel, Robert G. Robinson

Research output: Contribution to journalArticle

18 Scopus citations


This study examined the efficacy of antidepressant treatment for preventing the onset of generalized anxiety disorder (GAD) among patients with recent stroke. Of 799 patients assessed, 176 were randomized, and 149 patients without evidence of GAD at the initial visit were included in this doubleblind treatment with escitalopram (N=47) or placebo (N=49) or non-blinded problem-solving therapy (PST; 12 total sessions; N=53). Participants given placebo over 12 months were 4.95 times more likely to develop GAD than patients given escitalopram and 4.00 times more likely to develop GAD than patients given PST. Although these results should be considered preliminary, the authors found that both escitalopram and PST were effective in preventing new onset of post-stroke GAD.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
Publication statusPublished - Jan 1 2014
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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