Prevention of post-stroke generalized anxiety disorder, Using escitalopram or problem- solving therapy

Katsunaka Mikami, Ricardo E. Jorge, David J. Moser, Stephan Arndt, Mijin Jang, Ana Solodkin, Steven L. Small, Pasquale Fonzetti, Mark T. Hegel, Robert G. Robinson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This study examined the efficacy of antidepressant treatment for preventing the onset of generalized anxiety disorder (GAD) among patients with recent stroke. Of 799 patients assessed, 176 were randomized, and 149 patients without evidence of GAD at the initial visit were included in this doubleblind treatment with escitalopram (N=47) or placebo (N=49) or non-blinded problem-solving therapy (PST; 12 total sessions; N=53). Participants given placebo over 12 months were 4.95 times more likely to develop GAD than patients given escitalopram and 4.00 times more likely to develop GAD than patients given PST. Although these results should be considered preliminary, the authors found that both escitalopram and PST were effective in preventing new onset of post-stroke GAD.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume26
Issue number4
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Citalopram
Anxiety Disorders
Stroke
Placebos
Therapeutics
Antidepressive Agents

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Prevention of post-stroke generalized anxiety disorder, Using escitalopram or problem- solving therapy. / Mikami, Katsunaka; Jorge, Ricardo E.; Moser, David J.; Arndt, Stephan; Jang, Mijin; Solodkin, Ana; Small, Steven L.; Fonzetti, Pasquale; Hegel, Mark T.; Robinson, Robert G.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 26, No. 4, 01.01.2014, p. 323-328.

Research output: Contribution to journalArticle

Mikami, Katsunaka ; Jorge, Ricardo E. ; Moser, David J. ; Arndt, Stephan ; Jang, Mijin ; Solodkin, Ana ; Small, Steven L. ; Fonzetti, Pasquale ; Hegel, Mark T. ; Robinson, Robert G. / Prevention of post-stroke generalized anxiety disorder, Using escitalopram or problem- solving therapy. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2014 ; Vol. 26, No. 4. pp. 323-328.
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