Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor

Mark J. Czaja, Jun Xu, Elaine Alt

Research output: Contribution to journalArticle

181 Scopus citations

Abstract

Background/Aims: Considerable indirect evidence suggests that cytokine tumor necrosis factor α contributes to the hepatocellular damage caused by toxic liver injury. The effects of tumor necrosis factor α neutralization on liver cell injury were determined in an in vivo model of toxic liver injury. Methods: The in vivo effects of tumor necrosis factor α were examined in carbon tetrachloride liver injury through the administration of a soluble tumor necrosis factor receptor to neutralize the effects of this cytokine. Results: Soluble tumor necrosis factor receptor treatment decreased the degree of liver injury as measured by reduced levels of serum liver enzymes and improved histology. Soluble tumor necrosis factor receptor administration also lowered the mortality from a lethal dose of carbon tetrachloride from 60% to 16%. Tumor necrosis factor α neutralization had no detrimental effect on liver regeneration as determined by the timing of histone gene expression and postinjury liver weight. Conclusions: These data provide direct evidence for a role of tumor necrosis factor α in toxin-induced liver cell injury. In addition, these investigations suggest that soluble tumor necrosis factor receptor therapy may be of benefit in the treatment of human liver disease.

Original languageEnglish (US)
Pages (from-to)1849-1854
Number of pages6
JournalGastroenterology
Volume108
Issue number6
DOIs
StatePublished - Jun 1995

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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