Prevalence, risk factors, and accuracy of cytologic screening for cervical intraepithelial neoplasia in women with the human immunodeficiency virus

Mitchell Maiman, Rachel G. Fruchter, Alexander Sedlis, Joseph Feldman, Patrick Chen, Robert D. Burk, Howard Minkoff

Research output: Contribution to journalArticle

100 Scopus citations


Objectives. The objective was to evaluate the sensitivity and specificity of cervical cytology in women infected with the human immunodeficiency virus (HIV), risk factors for abnormal cytology in HIV- infected and uninfected women, and risk factors for histologic diagnosis of cervical intraepithelial neoplasia (CIN) in HIV-infected women. Methods. Methods included a cross-sectional analysis of cervical cytology, colposcopic impression, and histology in 248 HIV-infected women and multivariate analyses of risk factors for abnormal cytology in 253 HIV-infected and 220 uninfected women and risk factors for CIN in 186 HIV-infected women. Results. The sensitivity and specificity of cytology for all CIN grades were 0.60 and 0.80 and, for high-grade CIN, 0.83 and 0.74. The prevalence of abnormal cytology was 32.9% in HIV-infected and 7.6% in HIV-negative women. Independent risk factors for abnormal cytology were immunodeficiency [odds ratio (OR) 8-17, P < 0.001] and human papillomavirus (HPV) infection (OR = 5, P < 0.001). The prevalence of CIN on histology was 32% in HIV-infected women, and the only independent risk factor for CIN was oncogenic HPV type (OR = 5, P = 0.005). Conclusion. Given the high prevalence of abnormal cytology and CIN in HIV- infected women, cytologic screening has significant limitations. Both immunodeficiency and type of HPV infection are important risk factors.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalGynecologic Oncology
Issue number3
Publication statusPublished - Mar 1998


ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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