Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count

M. Gandhi; D. M. Koelle; N. Ameli; P. Bacchetti; J. S. Greenspan; M. Navazesh; K. Anastos; R. M. Greenblatt

doi:10.1177/154405910408300811

Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count

M. Gandhi, D. M. Koelle, N. Ameli, P. Bacchetti, J. S. Greenspan, M. Navazesh, K. Anastos, R. M. Greenblatt

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/μL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3-3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir > 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.

Original language	English (US)
Pages (from-to)	639-643
Number of pages	5
Journal	Journal of Dental Research
Volume	83
Issue number	8
DOIs	https://doi.org/10.1177/154405910408300811
State	Published - Aug 2004
Externally published	Yes

Keywords

CD4 count
HHV-8
HIV
Kaposi's sarcoma
Salivary shedding

ASJC Scopus subject areas

General Dentistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/154405910408300811

Cite this

@article{cd8a6621293743839611c07d5ac74b35,

title = "Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count",

abstract = "Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/μL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3-3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir > 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.",

keywords = "CD4 count, HHV-8, HIV, Kaposi's sarcoma, Salivary shedding",

author = "M. Gandhi and Koelle, {D. M.} and N. Ameli and P. Bacchetti and Greenspan, {J. S.} and M. Navazesh and K. Anastos and Greenblatt, {R. M.}",

note = "Funding Information: We thank Meei-Li Huang, PhD, at the University of Washington, Seattle, for performing the PCR assays for HHV-8 DNA on the WIHS specimens in this report. We also thank Lawrence Corey, MD, Head of the Virology Division, Department of Laboratory Medicine at the University of Washington, Seattle, for comments and suggestions on our study. Finally, we extend a heartfelt thanks to all of the WIHS participants who made this study possible. This study was funded by the National Institute of Dental and Craniofacial Research via NIAID U01- AI034989. This paper is based on a {\textquoteleft}Late Breaker{\textquoteright} oral presentation at the 40th Annual Meeting of the Infectious Diseases Society of America (IDSA), October 24–27, 2002, in Chicago (Abstract #200031). The authors have no financial interest in or financial conflict with the subject matter or materials discussed in this manuscript.",

year = "2004",

month = aug,

doi = "10.1177/154405910408300811",

language = "English (US)",

volume = "83",

pages = "639--643",

journal = "Journal of Dental Research",

issn = "0022-0345",

publisher = "SAGE Publications Inc.",

number = "8",

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TY - JOUR

T1 - Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count

AU - Gandhi, M.

AU - Koelle, D. M.

AU - Ameli, N.

AU - Bacchetti, P.

AU - Greenspan, J. S.

AU - Navazesh, M.

AU - Anastos, K.

AU - Greenblatt, R. M.

N1 - Funding Information: We thank Meei-Li Huang, PhD, at the University of Washington, Seattle, for performing the PCR assays for HHV-8 DNA on the WIHS specimens in this report. We also thank Lawrence Corey, MD, Head of the Virology Division, Department of Laboratory Medicine at the University of Washington, Seattle, for comments and suggestions on our study. Finally, we extend a heartfelt thanks to all of the WIHS participants who made this study possible. This study was funded by the National Institute of Dental and Craniofacial Research via NIAID U01- AI034989. This paper is based on a ‘Late Breaker’ oral presentation at the 40th Annual Meeting of the Infectious Diseases Society of America (IDSA), October 24–27, 2002, in Chicago (Abstract #200031). The authors have no financial interest in or financial conflict with the subject matter or materials discussed in this manuscript.

PY - 2004/8

Y1 - 2004/8

N2 - Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/μL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3-3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir > 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.

AB - Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/μL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3-3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir > 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.

KW - CD4 count

KW - HHV-8

KW - HIV

KW - Kaposi's sarcoma

KW - Salivary shedding

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C2 - 15271974

AN - SCOPUS:4444305383

SN - 0022-0345

VL - 83

SP - 639

EP - 643

JO - Journal of Dental Research

JF - Journal of Dental Research

IS - 8

ER -

Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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