Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count

M. Gandhi, D. M. Koelle, N. Ameli, P. Bacchetti, J. S. Greenspan, M. Navazesh, Kathryn Anastos, R. M. Greenblatt

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/μL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3-3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir > 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.

Original languageEnglish (US)
Pages (from-to)639-643
Number of pages5
JournalJournal of Dental Research
Volume83
Issue number8
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

Human Herpesvirus 8
CD4 Lymphocyte Count
HIV
Kaposi's Sarcoma
Saliva
DNA
Body Fluids
Virus Diseases

Keywords

  • CD4 count
  • HHV-8
  • HIV
  • Kaposi's sarcoma
  • Salivary shedding

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Gandhi, M., Koelle, D. M., Ameli, N., Bacchetti, P., Greenspan, J. S., Navazesh, M., ... Greenblatt, R. M. (2004). Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count. Journal of Dental Research, 83(8), 639-643.

Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count. / Gandhi, M.; Koelle, D. M.; Ameli, N.; Bacchetti, P.; Greenspan, J. S.; Navazesh, M.; Anastos, Kathryn; Greenblatt, R. M.

In: Journal of Dental Research, Vol. 83, No. 8, 08.2004, p. 639-643.

Research output: Contribution to journalArticle

Gandhi, M, Koelle, DM, Ameli, N, Bacchetti, P, Greenspan, JS, Navazesh, M, Anastos, K & Greenblatt, RM 2004, 'Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count', Journal of Dental Research, vol. 83, no. 8, pp. 639-643.
Gandhi M, Koelle DM, Ameli N, Bacchetti P, Greenspan JS, Navazesh M et al. Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count. Journal of Dental Research. 2004 Aug;83(8):639-643.
Gandhi, M. ; Koelle, D. M. ; Ameli, N. ; Bacchetti, P. ; Greenspan, J. S. ; Navazesh, M. ; Anastos, Kathryn ; Greenblatt, R. M. / Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count. In: Journal of Dental Research. 2004 ; Vol. 83, No. 8. pp. 639-643.
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