Prevalence of hippocampal malrotation in a population without seizures

R. P. Gamss, Shira E. Slasky, Jacqueline A. Bello, Todd S. Miller, Shlomo Shinnar

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE: Hippocampal malrotation (HIMAL) is a failure of hippocampal inversion that occurs during normal fetal development and has been seen on MR imaging examinations of people with epilepsy, but it has not been studied in patients without epilepsy. We intended to evaluate the prevalence of HIMAL in MR imaging examinations of patients without seizures to better understand the significance of HIMAL in the population with seizure. MATERIALS AND METHODS: A total of 497 MR imaging examinations with thin-section imaging through the temporal lobes of patients referred for conditions other than seizures were reviewed. The examinations were performed on 1.5T magnets. Sagittal T1-weighted and coronal T2-weighted images were used to evaluate each MR image for the distinctive features of HIMAL. As previously described in the literature, the criteria for HIMAL include unilateral involvement and incomplete rotation of a hippocampus that is normal in size and signal intensity but abnormally rounded in shape, with blurred inner structure. In addition, ipsilateral findings of an atypical collateral sulcus angle and atypical position and size of the fornix were noted. The corpus callosum is normal, and the temporal lobe remains normal in size, though the temporal horn may appear enlarged. RESULTS: None of the patients' examinations fulfilled all of the HIMAL criteria. Six studies satisfied 2 or more criteria, which included an abnormally rounded hippocampus and a vertical collateral sulcus. These HIMAL findings were all seen on the left. Forniceal asymmetry was the most prevalent abnormality, with 289 patients manifesting a low position of 1 fornix. CONCLUSIONS: Hippocampal malrotation is a rare finding in patients without seizures. HIMAL is therefore likely to be a pathologic finding.

Original languageEnglish (US)
Pages (from-to)1571-1573
Number of pages3
JournalAmerican Journal of Neuroradiology
Volume30
Issue number8
DOIs
StatePublished - Sep 2009

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Seizures
Temporal Lobe
Population
Epilepsy
Hippocampus
Magnets
Corpus Callosum
Fetal Development

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Prevalence of hippocampal malrotation in a population without seizures. / Gamss, R. P.; Slasky, Shira E.; Bello, Jacqueline A.; Miller, Todd S.; Shinnar, Shlomo.

In: American Journal of Neuroradiology, Vol. 30, No. 8, 09.2009, p. 1571-1573.

Research output: Contribution to journalArticle

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