Prevalence of elevated right ventricular pressure in children with obstructive sleep apnea syndrome undergoing pulmonary hypertension screening

Anna C. Bitners, Raanan Arens, Joseph Mahgerefteh, Nicole J. Sutton, Ellen J. Silver, Sanghun Sin, Masrur A. Khan, Christina J. Yang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Study Objectives: Our objective was to determine the prevalence of elevated right ventricular pressure (RVP) as a surrogate marker for pulmonary hypertension in children with obstructive sleep apnea syndrome (OSAS) undergoing echocardiography. Methods: This was a retrospective chart review of children ages 2–21 years diagnosed with OSAS by an overnight polysomnogram who underwent cardiac echocardiogram to screen for pulmonary hypertension within 6 months of polysomnogram in a tertiary inner-city pediatric hospital. The primary outcome was elevated RVP defined by estimated RVP ≥ 25 mm Hg above right atrial pressure or ventricular septal configuration consistent with elevated RVP. Results: A total of 174 children were included. The median (interquartile range) age was 8.9 (5.5–13.1) years with 59.2% male, 41.4% Hispanic, and 25.9% non-Hispanic Black patients. The prevalence of obesity was 72.0% and severe or very severe OSAS was present in 93.1%. The median (interquartile range) apnea-hypopnea index was 28.3 events/h (18.8–52.7 events/h). Seven children (4.0%) had elevated RVP. There was no association between elevated RVP and age, sex, race, body mass index percentile, apnea-hypopnea index, oxygen nadir, or severe OSAS (apnea-hypopnea index ≥ 10 events/h). Conclusions: Elevated RVP was rare and was not associated with OSAS severity. The prevalence in this cohort is higher than the prevalence of pulmonary hypertension noted in similar studies (0%–1.8%), which may be related to differences in methodology or unassessed cohort characteristics. Further effort to determine the optimal role for pulmonary hypertension screening in pediatric OSAS is needed.

Original languageEnglish (US)
Pages (from-to)2225-2232
Number of pages8
JournalJournal of Clinical Sleep Medicine
Volume17
Issue number11
DOIs
StatePublished - Nov 1 2021

Keywords

  • echocardiogram
  • obstructive sleep apnea syndrome
  • pediatrics
  • pulmonary hypertension

ASJC Scopus subject areas

  • Medicine(all)

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