Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women

Linda Ahdieh, Robert S. Klein, Robert Burk, Susan Cu-Uvin, Paula Schuman, Ann Duerr, Mahboobeh Safaeian, Jacquie Astemborski, Richard Daniel, Keerti Shah

Research output: Contribution to journalArticle

245 Scopus citations

Abstract

Human immunodeficiency virus (HIV) infection and related immunosuppression are associated with excess risk for cervical neoplasia and human papillomavirus (HPV) persistence. Type-specific HPV infection was assessed at 6-month intervals for HIV-positive and HIV-negative women (median follow-up, 2.5 and 2.9 years, respectively). The type-specific incidence of HPV infection was determined, and risk factors for HPV persistence were investigated by statistical methods that accounted for repeated measurements. HIV-positive women were 1.8, 2.1, and 2.7 times more likely to have high-, intermediate-, and low-risk HPV infections, respectively, compared with HIV-negative women. In multivariate analysis, high viral signal, but not viral risk category, was independently associated with persistence among HIV-positive subjects (odds ratio [OR], 2.5; 95% confidence interval [CI], 2.1-2.9). Furthermore, persistence was 1.9 (95% CI, 1.5-2.3) times greater if the subject had a CD4 cell count <200 cells/μL (vs. >500 cells/μL). Thus, HIV infection and immunosuppression play an important role in modulating the natural history of HPV infection.

Original languageEnglish (US)
Pages (from-to)682-690
Number of pages9
JournalJournal of Infectious Diseases
Volume184
Issue number6
DOIs
StatePublished - Sep 15 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Ahdieh, L., Klein, R. S., Burk, R., Cu-Uvin, S., Schuman, P., Duerr, A., Safaeian, M., Astemborski, J., Daniel, R., & Shah, K. (2001). Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women. Journal of Infectious Diseases, 184(6), 682-690. https://doi.org/10.1086/323081