TY - JOUR
T1 - Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women
AU - Ahdieh, Linda
AU - Klein, Robert S.
AU - Burk, Robert
AU - Cu-Uvin, Susan
AU - Schuman, Paula
AU - Duerr, Ann
AU - Safaeian, Mahboobeh
AU - Astemborski, Jacquie
AU - Daniel, Richard
AU - Shah, Keerti
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2001/9/15
Y1 - 2001/9/15
N2 - Human immunodeficiency virus (HIV) infection and related immunosuppression are associated with excess risk for cervical neoplasia and human papillomavirus (HPV) persistence. Type-specific HPV infection was assessed at 6-month intervals for HIV-positive and HIV-negative women (median follow-up, 2.5 and 2.9 years, respectively). The type-specific incidence of HPV infection was determined, and risk factors for HPV persistence were investigated by statistical methods that accounted for repeated measurements. HIV-positive women were 1.8, 2.1, and 2.7 times more likely to have high-, intermediate-, and low-risk HPV infections, respectively, compared with HIV-negative women. In multivariate analysis, high viral signal, but not viral risk category, was independently associated with persistence among HIV-positive subjects (odds ratio [OR], 2.5; 95% confidence interval [CI], 2.1-2.9). Furthermore, persistence was 1.9 (95% CI, 1.5-2.3) times greater if the subject had a CD4 cell count <200 cells/μL (vs. >500 cells/μL). Thus, HIV infection and immunosuppression play an important role in modulating the natural history of HPV infection.
AB - Human immunodeficiency virus (HIV) infection and related immunosuppression are associated with excess risk for cervical neoplasia and human papillomavirus (HPV) persistence. Type-specific HPV infection was assessed at 6-month intervals for HIV-positive and HIV-negative women (median follow-up, 2.5 and 2.9 years, respectively). The type-specific incidence of HPV infection was determined, and risk factors for HPV persistence were investigated by statistical methods that accounted for repeated measurements. HIV-positive women were 1.8, 2.1, and 2.7 times more likely to have high-, intermediate-, and low-risk HPV infections, respectively, compared with HIV-negative women. In multivariate analysis, high viral signal, but not viral risk category, was independently associated with persistence among HIV-positive subjects (odds ratio [OR], 2.5; 95% confidence interval [CI], 2.1-2.9). Furthermore, persistence was 1.9 (95% CI, 1.5-2.3) times greater if the subject had a CD4 cell count <200 cells/μL (vs. >500 cells/μL). Thus, HIV infection and immunosuppression play an important role in modulating the natural history of HPV infection.
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U2 - 10.1086/323081
DO - 10.1086/323081
M3 - Article
C2 - 11517428
AN - SCOPUS:0035884458
SN - 0022-1899
VL - 184
SP - 682
EP - 690
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -