Prevalence and correlates of anemia in a large cohort of HIV-infected women

Women's interagency hiv study

Alexandra M. Levine, Kiros Berhane, Lena Masri-Lavine, Maria Lynn Sanchez, Mary Young, Michael Augenbraun, Mardge Cohen, Kathryn Anastos, Margaret Newman, Stephen J. Gange, Heather Watts

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Anemia is a common manifestation of HIV infection, occurring in approximately 30% of patients with asymptomatic infection and in as many as 75% to 80% of those with AIDS. Anemia has been associated with decreased quality of life and decreased survival. We performed a cross-sectional study nested within a multicenter prospective cohort study to describe the prevalence of anemia in 2056 HIV-infected and 569 HIV-negative women as well as to define the demographic, clinical, immunologic, and virologic correlates of anemia among HIV-infected women. A total of 37% of HIV-positive women and 17% of HIV-negative women had hemoglobin levels < 12 g/dl (p < .001). Factors associated with anemia in HIV-positive and HIV-negative women included mean corpuscular volume (MCV) < 80 fl (p < .001) and black race (p < .001). Among HIV-infected women, multivariate logistic analyses revealed that African American race (p < .0001), MCV < 80 fl (p < .0001), CD4 count < 200 per microliter (p < .0001), higher HIV RNA in plasma (p = .02), current use of ZDV (p = .01), and history of clinical AIDS (p = .004) were all independent predictors of anemia. These data indicate that worsening parameters of HIV disease are associated with anemia among HIV-infected women. Black women and women with low MCV values are at increased risk for anemia independent of HIV status.

Original languageEnglish (US)
Pages (from-to)28-35
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume26
Issue number1
StatePublished - Jan 1 2001

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Anemia
HIV
Erythrocyte Indices
Acquired Immunodeficiency Syndrome
Asymptomatic Infections
CD4 Lymphocyte Count
African Americans
HIV Infections
Hemoglobins
Cohort Studies
Multivariate Analysis
Cross-Sectional Studies
Quality of Life
Demography
Prospective Studies
RNA
Survival

Keywords

  • Anemia
  • HIV
  • Women

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Levine, A. M., Berhane, K., Masri-Lavine, L., Sanchez, M. L., Young, M., Augenbraun, M., ... Watts, H. (2001). Prevalence and correlates of anemia in a large cohort of HIV-infected women: Women's interagency hiv study. Journal of Acquired Immune Deficiency Syndromes, 26(1), 28-35.

Prevalence and correlates of anemia in a large cohort of HIV-infected women : Women's interagency hiv study. / Levine, Alexandra M.; Berhane, Kiros; Masri-Lavine, Lena; Sanchez, Maria Lynn; Young, Mary; Augenbraun, Michael; Cohen, Mardge; Anastos, Kathryn; Newman, Margaret; Gange, Stephen J.; Watts, Heather.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 26, No. 1, 01.01.2001, p. 28-35.

Research output: Contribution to journalArticle

Levine, AM, Berhane, K, Masri-Lavine, L, Sanchez, ML, Young, M, Augenbraun, M, Cohen, M, Anastos, K, Newman, M, Gange, SJ & Watts, H 2001, 'Prevalence and correlates of anemia in a large cohort of HIV-infected women: Women's interagency hiv study', Journal of Acquired Immune Deficiency Syndromes, vol. 26, no. 1, pp. 28-35.
Levine AM, Berhane K, Masri-Lavine L, Sanchez ML, Young M, Augenbraun M et al. Prevalence and correlates of anemia in a large cohort of HIV-infected women: Women's interagency hiv study. Journal of Acquired Immune Deficiency Syndromes. 2001 Jan 1;26(1):28-35.
Levine, Alexandra M. ; Berhane, Kiros ; Masri-Lavine, Lena ; Sanchez, Maria Lynn ; Young, Mary ; Augenbraun, Michael ; Cohen, Mardge ; Anastos, Kathryn ; Newman, Margaret ; Gange, Stephen J. ; Watts, Heather. / Prevalence and correlates of anemia in a large cohort of HIV-infected women : Women's interagency hiv study. In: Journal of Acquired Immune Deficiency Syndromes. 2001 ; Vol. 26, No. 1. pp. 28-35.
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