Abstract
Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 271-276 |
| Number of pages | 6 |
| Journal | Acta Psychiatrica Scandinavica |
| Volume | 117 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2008 |
| Externally published | Yes |
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Keywords
- Major depressive disorder
- Quantitative electroencephalography
- Selective serotonin reuptake inhibitors
- Suicidal ideation
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuroscience(all)
Cite this
Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder. / Iosifescu, D. V.; Greenwald, S.; Devlin, P.; Perlis, R. H.; Denninger, J. W.; Alpert, Jonathan E.; Fava, M.
In: Acta Psychiatrica Scandinavica, Vol. 117, No. 4, 04.2008, p. 271-276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder
AU - Iosifescu, D. V.
AU - Greenwald, S.
AU - Devlin, P.
AU - Perlis, R. H.
AU - Denninger, J. W.
AU - Alpert, Jonathan E.
AU - Fava, M.
PY - 2008/4
Y1 - 2008/4
N2 - Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.
AB - Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.
KW - Major depressive disorder
KW - Quantitative electroencephalography
KW - Selective serotonin reuptake inhibitors
KW - Suicidal ideation
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UR - http://www.scopus.com/inward/citedby.url?scp=40449095126&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0447.2008.01156.x
DO - 10.1111/j.1600-0447.2008.01156.x
M3 - Article
VL - 117
SP - 271
EP - 276
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 4
ER -