Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder

D. V. Iosifescu; S. Greenwald; P. Devlin; R. H. Perlis; J. W. Denninger; J. E. Alpert; M. Fava

doi:10.1111/j.1600-0447.2008.01156.x

Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder

D. V. Iosifescu, S. Greenwald, P. Devlin, R. H. Perlis, J. W. Denninger, J. E. Alpert, M. Fava

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.

Original language	English (US)
Pages (from-to)	271-276
Number of pages	6
Journal	Acta Psychiatrica Scandinavica
Volume	117
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0447.2008.01156.x
State	Published - Apr 2008
Externally published	Yes

Keywords

Major depressive disorder
Quantitative electroencephalography
Selective serotonin reuptake inhibitors
Suicidal ideation

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1600-0447.2008.01156.x

Cite this

@article{7948516fba254253ac532ab7ca2e96da,

title = "Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder",

abstract = "Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.",

keywords = "Major depressive disorder, Quantitative electroencephalography, Selective serotonin reuptake inhibitors, Suicidal ideation",

author = "Iosifescu, {D. V.} and S. Greenwald and P. Devlin and Perlis, {R. H.} and Denninger, {J. W.} and Alpert, {J. E.} and M. Fava",

year = "2008",

month = apr,

doi = "10.1111/j.1600-0447.2008.01156.x",

language = "English (US)",

volume = "117",

pages = "271--276",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder

AU - Iosifescu, D. V.

AU - Greenwald, S.

AU - Devlin, P.

AU - Perlis, R. H.

AU - Denninger, J. W.

AU - Alpert, J. E.

AU - Fava, M.

PY - 2008/4

Y1 - 2008/4

N2 - Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.

AB - Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.

KW - Major depressive disorder

KW - Quantitative electroencephalography

KW - Selective serotonin reuptake inhibitors

KW - Suicidal ideation

UR - http://www.scopus.com/inward/record.url?scp=40449095126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40449095126&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0447.2008.01156.x

DO - 10.1111/j.1600-0447.2008.01156.x

M3 - Article

C2 - 18307587

AN - SCOPUS:40449095126

SN - 0001-690X

VL - 117

SP - 271

EP - 276

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 4

ER -

Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this