Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder

D. V. Iosifescu; S. Greenwald; P. Devlin; R. H. Perlis; J. W. Denninger; J. E. Alpert; M. Fava

doi:10.1111/j.1600-0447.2008.01156.x

Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder

D. V. Iosifescu, S. Greenwald, P. Devlin, R. H. Perlis, J. W. Denninger, J. E. Alpert, M. Fava

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.

Original language	English (US)
Pages (from-to)	271-276
Number of pages	6
Journal	Acta Psychiatrica Scandinavica
Volume	117
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0447.2008.01156.x
State	Published - Apr 1 2008
Externally published	Yes

Keywords

Major depressive disorder
Quantitative electroencephalography
Selective serotonin reuptake inhibitors
Suicidal ideation

ASJC Scopus subject areas

Psychiatry and Mental health

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title = "Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder",

abstract = "Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.",

keywords = "Major depressive disorder, Quantitative electroencephalography, Selective serotonin reuptake inhibitors, Suicidal ideation",

author = "Iosifescu, {D. V.} and S. Greenwald and P. Devlin and Perlis, {R. H.} and Denninger, {J. W.} and Alpert, {J. E.} and M. Fava",

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AU - Greenwald, S.

AU - Devlin, P.

AU - Perlis, R. H.

AU - Denninger, J. W.

AU - Alpert, J. E.

AU - Fava, M.

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N2 - Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.

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KW - Suicidal ideation

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