Pretreatment EEG in childhood absence epilepsy

Dennis Dlugos, Shlomo Shinnar, Avital Cnaan, Fengming Hu, Solomon L. Moshe, Eli Mizrahi, David Masur, Yoshi Sogawa, J. B Le Pichon, Calley Levine, Deborah Hirtz, Peggy Clark, Peter C. Adamson, Tracy Glauser

Research output: Contribution to journalArticle

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Abstract

Objective: In children with newly diagnosed childhood absence epilepsy (CAE), determine pretreatment EEG features and their associations with baseline neuropsychological function and short-term treatment outcome. Methods: In a multicenter, randomized clinical trial, patients with CAE underwent a pretreatment, 1-hour video-EEG and neuropsychological testing with freedom-from-failure and seizure-freedom (SF) outcome assessed at the 16- to 20-week visit. Results: Detailed evaluation of the pretreatment EEG was possible for 99.8% of participants (445/446). Median time to first seizure was 6.0 minutes (range 0-59 minutes), median number of seizures was 5 (range 1-60), and median seizure duration was 10.8 seconds (range 3.3-77.6 seconds). Median duration of shortest seizure per EEG was 7.5 seconds (range 3.0-77.6 seconds). Seizure frequency was not associated with baseline measures of attention, executive function, or treatment outcome. Presence of a seizure lasting $20 seconds was noted in 29% of subjects (129/440); these children had higher median omissions T score on the Conners Continuous Performance Test (56.3 vs 51.6, p 5 0.01). Patients with a shortest seizure of longer duration were more likely to demonstrate treatment success by both freedom-from-failure (p5 0.02) and SF (p5 0.005) criteria, even after controlling for age, treatment group, and number of seizures, with good predictive value (area under the curve 78% for SF). Conclusions: CAE is reliably and quickly confirmed by EEG. Occurrence of a seizure $20 seconds, but not overall seizure frequency, was associated with differential baseline measures of attention. Patients whose shortest pretreatment EEG seizure was longer in duration were more likely to achieve SF, regardless of treatment.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalNeurology
Volume81
Issue number2
DOIs
StatePublished - Jul 9 2013

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Absence Epilepsy
Electroencephalography
Seizures
Epilepsy
Pretreatment
Childhood
Electroencephalogram
Executive Function

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Dlugos, D., Shinnar, S., Cnaan, A., Hu, F., Moshe, S. L., Mizrahi, E., ... Glauser, T. (2013). Pretreatment EEG in childhood absence epilepsy. Neurology, 81(2), 150-156. https://doi.org/10.1212/WNL.0b013e31829a3373

Pretreatment EEG in childhood absence epilepsy. / Dlugos, Dennis; Shinnar, Shlomo; Cnaan, Avital; Hu, Fengming; Moshe, Solomon L.; Mizrahi, Eli; Masur, David; Sogawa, Yoshi; Pichon, J. B Le; Levine, Calley; Hirtz, Deborah; Clark, Peggy; Adamson, Peter C.; Glauser, Tracy.

In: Neurology, Vol. 81, No. 2, 09.07.2013, p. 150-156.

Research output: Contribution to journalArticle

Dlugos, D, Shinnar, S, Cnaan, A, Hu, F, Moshe, SL, Mizrahi, E, Masur, D, Sogawa, Y, Pichon, JBL, Levine, C, Hirtz, D, Clark, P, Adamson, PC & Glauser, T 2013, 'Pretreatment EEG in childhood absence epilepsy', Neurology, vol. 81, no. 2, pp. 150-156. https://doi.org/10.1212/WNL.0b013e31829a3373
Dlugos, Dennis ; Shinnar, Shlomo ; Cnaan, Avital ; Hu, Fengming ; Moshe, Solomon L. ; Mizrahi, Eli ; Masur, David ; Sogawa, Yoshi ; Pichon, J. B Le ; Levine, Calley ; Hirtz, Deborah ; Clark, Peggy ; Adamson, Peter C. ; Glauser, Tracy. / Pretreatment EEG in childhood absence epilepsy. In: Neurology. 2013 ; Vol. 81, No. 2. pp. 150-156.
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AU - Dlugos, Dennis

AU - Shinnar, Shlomo

AU - Cnaan, Avital

AU - Hu, Fengming

AU - Moshe, Solomon L.

AU - Mizrahi, Eli

AU - Masur, David

AU - Sogawa, Yoshi

AU - Pichon, J. B Le

AU - Levine, Calley

AU - Hirtz, Deborah

AU - Clark, Peggy

AU - Adamson, Peter C.

AU - Glauser, Tracy

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N2 - Objective: In children with newly diagnosed childhood absence epilepsy (CAE), determine pretreatment EEG features and their associations with baseline neuropsychological function and short-term treatment outcome. Methods: In a multicenter, randomized clinical trial, patients with CAE underwent a pretreatment, 1-hour video-EEG and neuropsychological testing with freedom-from-failure and seizure-freedom (SF) outcome assessed at the 16- to 20-week visit. Results: Detailed evaluation of the pretreatment EEG was possible for 99.8% of participants (445/446). Median time to first seizure was 6.0 minutes (range 0-59 minutes), median number of seizures was 5 (range 1-60), and median seizure duration was 10.8 seconds (range 3.3-77.6 seconds). Median duration of shortest seizure per EEG was 7.5 seconds (range 3.0-77.6 seconds). Seizure frequency was not associated with baseline measures of attention, executive function, or treatment outcome. Presence of a seizure lasting $20 seconds was noted in 29% of subjects (129/440); these children had higher median omissions T score on the Conners Continuous Performance Test (56.3 vs 51.6, p 5 0.01). Patients with a shortest seizure of longer duration were more likely to demonstrate treatment success by both freedom-from-failure (p5 0.02) and SF (p5 0.005) criteria, even after controlling for age, treatment group, and number of seizures, with good predictive value (area under the curve 78% for SF). Conclusions: CAE is reliably and quickly confirmed by EEG. Occurrence of a seizure $20 seconds, but not overall seizure frequency, was associated with differential baseline measures of attention. Patients whose shortest pretreatment EEG seizure was longer in duration were more likely to achieve SF, regardless of treatment.

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