Preterm birth

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Preterm birth (PTB) is a perplexing clinical condition and major public health challenge. In 2006, 12.8% of all births in the United States were preterm, defined as occurring before 37 completed weeks of gestation. Preterm birth is the second leading cause of infant mortality and the leading cause of infant mortality among black infants in the United States, as well as the major contributor to worldwide infant mortality and morbidity. Despite the significant public health burden of PTB, there are few effective strategies to reliably predict or prevent PTB. The etiology of this common complex condition remains elusive. Efforts to identify environmental contributors suggest that smoking, stress, black race, nutritional deficits, and infection contribute to, but do not explain, the majority of PTBs. Therefore, the discovery of predisposing genetic variants and relevant geneenvironment interactions will likely be of great value in unraveling the mystery of PTB, by identifying women at risk and setting the stage for research and enhanced clinical and public health prevention strategies. This chapter discusses gene-disease associations PTBs.

Original languageEnglish (US)
Title of host publicationHuman Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition
PublisherOxford University Press
ISBN (Print)9780199776023, 9780195398441
DOIs
StatePublished - May 1 2010

Fingerprint

Premature Birth
Infant Mortality
Public Health
Smoking
Parturition
Morbidity
Pregnancy
Infection
Research
Genes

Keywords

  • Genetic variants
  • Genetic variations
  • Genome-wide studies
  • Human disease
  • Preterm birth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dolan, S. M. (2010). Preterm birth. In Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195398441.003.0018

Preterm birth. / Dolan, Siobhan M.

Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition. Oxford University Press, 2010.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dolan, SM 2010, Preterm birth. in Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195398441.003.0018
Dolan SM. Preterm birth. In Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition. Oxford University Press. 2010 https://doi.org/10.1093/acprof:oso/9780195398441.003.0018
Dolan, Siobhan M. / Preterm birth. Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition. Oxford University Press, 2010.
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